Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (6): 693-698.doi: 10.7518/gjkq.2020097

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Etiology and progress in the therapy of drug-induced gingival enlargement

Li Yan1,2(),Meng Chenda2,Xu Quanchen1,2()   

  1. 1. Dept. of Stomatology, Affiliated Hospital of Qingdao University, Qingdao 266003, China
    2. School of Stomatology, Qingdao University, Qingdao 266003, China
  • Received:2020-02-25 Revised:2020-06-30 Online:2020-11-01 Published:2020-11-06
  • Contact: Quanchen Xu E-mail:944058727@qq.com;qyfyxqc@126.com
  • Supported by:
    Shandong Province Key Research and Development Plan(2018GSF118150);National Natural Science Foundation of China(81500849)

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Abstract:

Drug-induced gingival enlargement (DIGE) refers to gingival fibrosis hyperplasia and volume enlargement caused by long-term use of certain drugs. DIGE can cause serious damage to the oral health of patients. Its etiology is unclear, and treatment is difficult. This article will discuss the research progress of the etiology of DIGE from five aspects: inflammation, the Wnt/β-catenin signaling pathway, epithelial-mesenchymal transition, integrin, and matrix metalloproteinase. Therapeutic progress is reviewed from four aspects of non-surgical treatment, surgical treatment, drug therapy and adjuvant therapy to provide a certain reference value for subsequent research and treatment.

Key words: drug-induced gingival enlargement, nifedipine, phenytoin, cyclosporine

CLC Number: 

  • R781.4

TrendMD: 
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