Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (5): 565-568.doi: 10.7518/gjkq.2016.05.016

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Structural function and pathogenic mechanism of cytolethal distending toxin and outer membrane proteins

Sun Fei1, Zhang Jiangang2, Xiao Shuiqing2   

  1. 1. Dept. of Orthodontics, School of Stomatology, Binzhou Medical College, Binzhou 256603, China; 2. Dept. of Orthodontics, Jinan Stomatological Hospital, Jinan 250001, China
  • Received:2015-12-23 Revised:2016-06-15 Online:2016-09-01 Published:2016-09-01

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Abstract: Actinobacillus actinomycetemcomitans(A.actinomycetemcomitans) is the main pathogenic bacteria of juvenile periodontal diseases and is associated with aggressive periodontitis. A.actinomycetemcomitans cells secrete synthetic cytolethal distending toxin(CDT) and outer membrane protein(OMP), which can be easily planted into the host to destroy immunity function. Thus, the presence of these molecules leads to the progression of periodontal tissue destruction and periodontal diseases. This paper mainly describes the structural function and pathogenic mechanism of the two virulence factors, namely, CDT and OMP, for further research.

Key words: Actinobacillus actinomycetemcomitans, cytolethal distending toxin, outer membrance proteins

CLC Number: 

  • R 780.2

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