Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (3): 357-360.doi: 10.7518/gjkq.2016.03.023

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Role of transformer 2 regulation and its physiological and pathological significance

Ning Yi1, Zheng Xiaoxu2, Sun Rui3   

  1. 1. College of Stomatology, Shanxi Medical University, Taiyuan 030001, China; 2. Dept. of Nephrology, Affiliated Hospital of Medical College, University of Maryland, Baltimore 21201, America; 3. Dept.of Oral and Maxillofacial Surgery, Shanxi Provincial People’s Hospital, Taiyuan 030012, China) This study was supported by the Natural Science Foundation of Shanxi Province(2011011037).
  • Received:2015-06-06 Revised:2016-02-02 Online:2016-05-01 Published:2016-05-01

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Abstract: The transformer(TRA)2 protein belongs to the serine/arginine-rich(SR) protein family. The protein possesses two homologs, namely, TRA2α and TRA2β. These homologs exhibit structures similar to those of the SR proteins but significantly differ in function. TRA2 is not necessarily implicated in composition splicing but plays an important role in selecting the splicing sites of precursor mRNA. Further studies found that in mammals, the TRA2 family protein plays a key role in many physiological and pathological, as well as disease occurrence and development, processes. Moreover, the abnormal splicing process of RNA molecules can cause disease or aggravate existing pathological problems. However, the relationship between TRA2 proteins and diseases remains to be completely understood. Additional energy and effort are required to achieve success in investigating disease causes and in developing treatments.

Key words: transformer, precursor mRNA splicing protein, physiological and pathological effect, disease control, transformer, precursor mRNA splicing protein, physiological and pathological effect, disease control

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  • Q 51

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（本文采编 王晴）
[1] Hao Fu,Ning Yi,Sun Rui,Zheng Xiaoxu. Expression and potential clinical significance of Transformer 2β in oral squamous cell carcinoma [J]. Int J Stomatol, 2020, 47(2): 159-165.
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