Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (2): 220-222.doi: 10.7518/gjkq.2016.02.023

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The progress of relationship between primary trigeminal neuralgia and herpes simplex virus infection

Xu Peng, Chen Chuanjun   

  1. Dept. of Oral and Maxillofacial Surgery, The Affiliated Third Hospital of Anhui Medical University, Hefei 230032, China)
  • Received:2015-07-12 Revised:2015-12-14 Online:2016-03-01 Published:2016-03-01

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Abstract: The etiology and pathogenesis of primary trigeminal neuralgia(PTN) is unclear. Recent research reveals that PTN is related to the latency of herpes simplex virus(HSV). The trigeminal ganglia and nerve root in patients with PTN present obvious demyelination changes, which are the main pathological bases of PTN. Depending on its neurotropism, HSV infects the semilunar ganglion of trigeminal nerve and becomes latent for a long time. HSV is activated again when the body immunity is low, causing chronic inflammation of the trigeminal nerve and leading to demyelinating lesions and PTN. Interpretation of the etiology and pathogenesis of PTN would be important clinical significance for revealing the mystery of trigeminal neuralgia and creation and use of targeted therapy.

Key words: primary trigeminal neuralgia, herpes simplex virus, ganglion, demyelination, primary trigeminal neuralgia, herpes simplex virus, ganglion, demyelination

CLC Number: 

  • R 780.2

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（本文采编 王晴）
[1] LIU An -dong, LEI Jie, WANG Yuan-yin, ZHOU Jian. Research progress of trigeminal neuralgia and P2X receptors [J]. Inter J Stomatol, 2010, 37(02): 174-174～177.
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