Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (6): 786-789.doi: 10.7518/gjkq.2013.06.023

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WNT signal and its relation with cleft lip and palate

Cai Shengqing, Wang Yan, Shi Bing   

  1. State Key Laboratory of Oral Diseases, Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2013-01-31 Revised:2013-06-08 Online:2013-11-01 Published:2013-11-01

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Abstract:

WNT signal is involved in embryonic development. It is mainly involved in cell proliferation, differentiation, polarization, apoptosis, and anti-apoptosis. Recently, it has become the focus of many research. Cleft lip and palate are the major congenital malformations, and their pathogenesis is unclear. The WNT signal has been shown to have a close relationship with cleft lip and palate. This review summarized the research progress of WNT signal and its relation with cleft lip and palate.

Key words: WNT signaling, signal transduction, cleft lip, cleft palate, happen

CLC Number: 

  • R 782.2

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