Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (2): 269-272.doi: 10.3969/j.issn.1673-5749.2012.02.037

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Molecular mechanism of sclerostin on bone remoldling

Lin Tingting, Lu Eryi.   

  1. Dept. of Prosthodontics, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
  • Received:2011-07-26 Revised:2011-11-19 Online:2012-03-01 Published:2012-03-01

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Abstract:

Sclerostin is a negative regulator of osteoblasts. It is expressed exclusively by osteocytes which is transported to osteoblasts at the bone surface to inhibit bone formation. The mechanism of the sclerostin on bone is related to Wnt signaling pathway. The expression of sclerostin is also affected by the hormone, mechanical strain and hypoxia. The antibody to sclerostin has the ability to stimulate osteoblast activity and increase the bone mass, but the curative effect and safety need to estimate.

Key words: sclerostin, bone remoldling, Wnt signaling pathway


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