Abstract: Objective To compare the haemodynamics and awake grade influence to children between intravenous infusion remifentanil complexed propofol and ketamine complexed propofol by micro pump in children′s cleft lip repair. Methods We choosed 600 children with cleft lip whose age were 3 to 12 months and Ⅰ to Ⅱ grade in ASA and divided them into remifentanil complexed propofol group（group R） and ketamine complexed propofol group（group K） in random. Every group had 300 cases. After anesthesia induction routly, group R was anesthetized by intravenous infusion remifentanil complexed propofol and group K was anesthetized by ketamine complexed propofol. Two groups were band snuff air tube with reserve air bag and remained spontaneously breathing. All drugs were stopped 5 minutes before the end of the operation. During operation, heart rate, blood pressure, respiration rate, saturation of blood oxygen, tease tube time and awake grade were recorded. Results During operation, blood pressure and heart rate were higher in group K than in group R. Awake grade and tease tube time were longer in group K than in group R. There was a significant difference between two groups（P <0.05）. However, there were not significant difference between respiration rate and saturation of blood oxygen. Conclusion The method of intravenous infusion remifentanil complexed propofol by micro pump was better in children ′s cheilognathus prothesis operation.

Key words: remifentanil, ketamine, hemodynamics, anesthesia, children′s cleft lip