国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (6): 816-822.doi: 10.7518/gjkq.2025064

• 综述 • 上一篇    下一篇

大气冷等离子体在口腔组织再生中的研究进展

姚琳1(),邹玲1,刘显2()   

  1. 1.口腔疾病防治全国重点实验室;国家口腔医学中心 国家口腔疾病临床医学研究中心;四川大学华西口腔医院牙体牙髓病科 成都 610041
    2.口腔疾病防治全国重点实验室;国家口腔医学中心 国家口腔疾病临床医学研究中心;四川大学华西口腔医院口腔急诊科 成都 610041
  • 收稿日期:2024-06-30 修回日期:2025-02-21 出版日期:2025-11-01 发布日期:2025-10-23
  • 通讯作者: 刘显
  • 作者简介:姚琳，硕士，Email：yaolincc@163.com
  • 基金资助:
    四川省自然科学基金(2024NSFSC0536)

Research progress on cold atmosphere plasma in oral tissue regeneration

Lin Yao1(),Ling Zou1,Xian Liu2()   

  1. 1.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Emergency Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-06-30 Revised:2025-02-21 Online:2025-11-01 Published:2025-10-23
  • Contact: Xian Liu
  • Supported by:
    the Natural Science Foundation of Sichuan Province(2024NSFSC0536)

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摘要：

大气冷等离子体（CAP）是一种能在低温和大气压下工作的电离气体，它包含高度活跃的活性氧（ROS）和活性氮（RNS），在细胞信号传导、免疫响应等生理过程中发挥了重要作用。近年来CAP在口腔医学的应用受到广泛关注，其具备优异的抗菌、抗炎和组织修复的能力，有助于口腔内伤口愈合；此外，其表面修饰能力，可增强牙体组织或种植体与周围组织的相容性。因此，CAP在口腔软硬组织的再生方面具有很广阔的应用前景，能够缓解口腔疾病症状、缩短治疗时间和提高治疗效果。本文回顾并综述了近年来CAP在口腔组织再生中研究进展，为其临床应用提供参考。

关键词: 大气冷等离子体, 黏膜组织再生, 骨组织再生, 材料表面改性

Abstract:

Cold atmospheric plasma (CAP) is an ionized gas that works under low temperatures and atmospheric pressure. It contains highly active reactive oxygen species and reactive nitrogen species, which play important roles in cell signaling, immune response, and other physiological processes. The application of CAP in stomatology has received increa-sing attention due to its excellent antibacterial, anti-inflammatory, and tissue-repairing abilities, which contribute to wound healing in the oral cavity. Furthermore, its surface modification ability can enhance the compatibility between dental tissues or implants and surrounding tissues. Therefore, CAP displays broad application prospects in the regeneration of oral soft and hard tissues, alleviation of oral disease symptoms, shortening of treatment course, and improvement of therapeutic effect. This article reviews the research progress on the utilization of CAP in oral tissue regeneration to provide a refe-rence for its clinical application.

Key words: cold atmospheric plasma, mucosal tissue regeneration, bone tissue regeneration, material surface modification

中图分类号: 

  • R78
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