国际口腔医学杂志

国际口腔医学杂志 ›› 2024, Vol. 51 ›› Issue (6): 756-762.doi: 10.7518/gjkq.2024076

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泛连接蛋白调控口颌面疼痛作用及机制的研究进展

冯玉衡(),刘飞,张艳艳,沈颉飞()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院修复科 成都 610041
  • 收稿日期:2024-04-08 修回日期:2024-05-23 出版日期:2024-11-01 发布日期:2024-11-04
  • 通讯作者: 沈颉飞
  • 作者简介:冯玉衡，硕士，Email：Fqqaioth@163.com
  • 基金资助:
    国家自然科学基金(81870800)

Research progress on the role and mechanism of pannexins in regulating oral and orofacial pain

Yuheng Feng(),Fei Liu,Yanyan Zhang,Jiefei Shen()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-04-08 Revised:2024-05-23 Online:2024-11-01 Published:2024-11-04
  • Contact: Jiefei Shen
  • Supported by:
    National Natural Science Foundation of China(81870800)

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摘要：

口颌面疼痛的病理机制复杂，临床上目前仍缺乏持久有效的治疗手段，给患者生活带来沉重负担。近年来，研究表明外周和中枢神经系统中的泛连接蛋白（PANX）在调控口颌面部疼痛的发生和发展中发挥着重要作用。本文重点阐述PANX的结构和功能，以及其在疼痛中的作用和机制，包括口颌面部的神经病理性疼痛、炎性疼痛和其他疼痛。通过深入了解PANX在口颌面部疼痛中的作用和功能，以期为口颌面部疼痛的诊断与治疗提供理论基础和治疗策略。

关键词: 泛连接蛋白, 口颌面神经病理性疼痛, 信号通路, 三叉神经节

Abstract:

The pathological mechanism of orofacial pain is complex, and long-lasting effective clinical treatment me-thods are lacking, causing a heavy burden on patients’ lives. Pannexins (PANX), which are broadly expressed in the peri-pheral and central nervous systems, play a crucial role in regulating the development of orofacial pain. This review focuses on the structure and function of PANX as well as its role and mechanism in pain, including neuropathic pain, inflammatory pain, and other orofacial pain. We aim to provide a theoretical basis and treatment strategies for the diagnosis and treatment of orofacial pain by gaining a deep understanding of the role and function of PANX.

Key words: pannexin, orafacial neuropathic pain, signaling pathways, trigeminal ganglion

中图分类号: 

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