国际口腔医学杂志

国际口腔医学杂志 ›› 2024, Vol. 51 ›› Issue (2): 217-226.doi: 10.7518/gjkq.2024014

• 综述 • 上一篇    下一篇

三叉神经痛动物模型的研究现状

何科泰(),徐名颉,周昶含,米金龙,李忆博,刘磊()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院创伤整形外科 成都 610041
  • 收稿日期:2023-04-05 修回日期:2023-10-29 出版日期:2024-03-01 发布日期:2024-03-11
  • 通讯作者: 刘磊
  • 作者简介:何科泰，学士，Email：1441226538@qq.com
  • 基金资助:
    四川省科学技术厅应用基础研究项目(2020YJ0278)

Current status of animal model on trigeminal neuralgia

Ketai He(),Mingjie Xu,Changhan Zhou,Jinlong Mi,Yibo Li,Lei Liu()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Trauma and Reconstruction Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-04-05 Revised:2023-10-29 Online:2024-03-01 Published:2024-03-11
  • Contact: Lei Liu
  • Supported by:
    Applied Basic Research Programs of Science and Technology Department of Sichuan Province(2020YJ0278)

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摘要：

三叉神经痛是口腔医学的临床常见病，表现为电击样剧烈疼痛，严重影响患者的生活和工作。三叉神经痛可分为3种，其发病原因及特点各有不同，其中，经典型三叉神经痛的主要发病机制是机械压迫，炎症因子对该过程也有重要影响。建立合适的三叉神经痛动物模型对于理解该病的病因和发病机制具有重要作用，也是研究三叉神经痛治疗措施的实验方法学基础。目前学者们已经建立了多种三叉神经痛动物模型，适用于不同的实验目的和场景。本文对三叉神经痛动物实验模型的研究现状作一综述。

关键词: 三叉神经痛, 动物模型, 发病机制

Abstract:

Trigeminal neuralgia is a common clinical disease in stomatology. It is characterized by severe pain like electric shock, thereby seriously affecting the life and work of patients. Trigeminal neuralgia can be divided into three types with different causes and characteristics. Among them, classical trigeminal neuralgia has the main pathogenesis of mechanical compression, and inflammatory factors also significantly affect this process. Establishing an appropriate animal model of trigeminal neuralgia plays an important role in understanding the etiology and pathogenesis of the disease. Such a model can also serve as the experimental methodological basis for studying the treatment of trigeminal neuralgia. Scho-lars have established various trigeminal neuralgia animal models for different experimental purposes and scenarios. This article reviews the research status of animal experimental models of trigeminal neuralgia.

Key words: trigeminal neuralgia, animal model, pathogenesis

中图分类号: 

  • R783.4
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