国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (2): 195-200.doi: 10.7518/gjkq.2016.02.018
徐孟丹,邹多宏
Xu Mengdan, Zou Duohong
摘要: 低血性疾病危害性大,致死、致残率高,已成为临床医学面临的难题之一,而血运重建对低血性疾病有明显疗效。血管发生和成熟需要多种血管生长因子在特定的时间空间和质量浓度下共同作用,正常的脉管系统需要血管内皮生长因子(VEGF)表达在时间和空间上的精确控制。在不同的时间和特定的微环境下,同一种生长因子的质量浓度亦不相同,也起着不同的作用,例如转化生长因子-β1、VEGF受体和低氧诱导因子等。在血管生成和组织功能重建过程中,血管新生的方向性受内皮细胞和平滑肌细胞定向迁移的影响,分支形态发生也受VEGF空间梯度的高度调节,体现出VEGF表达的空间分布特性。血管生长因子的时间空间控制需建立组织内细胞因子的定量标准,从而精确地控制损伤组织部位血管形成;寻找合适的传递系统,使组织内生长因子达到特定的部位。了解血管生长因子的时间、空间特性对新生血管的构建具有重要的作用,合理利用血管生长因子的这一特性,将为治疗血管性疾病提供更多的选择。
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