国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (4): 391-397.doi: 10.7518/gjkq.2021072

• 牙周专栏 • 上一篇    下一篇

引导组织/骨再生牙周功能梯度膜的研究进展

赵文俊(),陈宇()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院病理科 成都 610041
  • 收稿日期:2021-01-25 修回日期:2021-04-12 出版日期:2021-07-01 发布日期:2021-06-30
  • 通讯作者: 陈宇
  • 作者简介:赵文俊,主治医师,博士,Email: 361321480@qq.com
  • 基金资助:
    四川省国际科技创新合作项目(2019YFH0024);成都市技术创新研发项目(2018-YF05-01233-SN)

Research progress on periodontal functional gradient membrane for guided tissue/bone regeneration

Zhao Wenjun(),Chen Yu()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-01-25 Revised:2021-04-12 Online:2021-07-01 Published:2021-06-30
  • Contact: Yu Chen
  • Supported by:
    Sichuan International Science and technology innovation cooperation project(2019YFH0024);Chengdu Technology Innovation Research and development project(2018-YF05-01233-SN)

摘要:

生物屏障膜(BBM)的应用是引导组织/骨再生(GTR/GBR)技术的关键环节,其主要作用是将牙周缺损区与牙龈组织相隔离,防止牙龈上皮组织向下方的牙周缺损区快速生长,从而为牙周组织的再生创造一个相对封闭的良好环境。理想的BBM应具有足够的机械强度、良好的促成骨及抗炎等诸多性能,然而目前使用的BBM均未能兼顾上述要求,均具有不同程度的缺点,GTR/GBR效果不理想。因此学者们广泛展开了对新一代可吸收GBR/GTR膜的开发和研究。在目前研究较为充分的BBM中,功能梯度膜(FGM)具有提升BBM诸多特性,使之更趋于理想的强大潜力,有增强临床GTR/GBR效果的广阔前景。本文对功能梯度GBR/GTR膜的研究进展进行综述,旨在为其进一步研究和开发提供参考。

关键词: 生物屏障膜, 功能梯度膜, 仿生, 引导组织再生, 引导骨再生

Abstract:

The application of biological barrier membrane (BBM) is the key role in guided tissue/bone regeneration (GTR/GBR) technology. Its main function is to isolate the periodontal defect area from gingival tissue, and prevent the gingival epithelial tissue from growing rapidly into the defect area, so as to create a relatively closed and profitable environment for periodontal tissue regeneration. The ideal BBM should have enough mechanical strength, promoting osteogenesis and anti-inflammatory properties. However, the effect of the current commercially GTR/GBR membranes cannot meet the above ideal requirements, and have different degrees of defects. Therefore, scholars have widely carried out the development and research on the new generation of bioabsorbable GBR/GTR membranes. Of the deeply and extensively researched BBM, FGM has great potential to possess the properties of ideal BBM. It has a broad prospect to enhance the clinical effect of GBR/GTR. In this paper, the research progress of functional gradient GBR/GTR membrane is reviewed, in order to provide reference for its further research and development.

Key words: biological barrier membrane, functional gradient membrane, biomimetic, guided tissue regeneration, guided bone regeneration

中图分类号: 

  • R318

图1

FGM呈阶梯或连续变化示意图 A:FGM的组成随距离呈阶梯样变化;B:FGM的组成随距离呈连续变化。"

图 2

Bottino MC设计的FGM结构示意图"

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