国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (2): 191-196.doi: 10.7518/gjkq.2019020

• 牙周专栏 • 上一篇    下一篇

釉原蛋白在牙周组织再生中的生物学作用

杨宇轩,张海霞,王爽()   

  1. 西安交通大学口腔医院正畸科 西安 710004
  • 收稿日期:2018-06-25 修回日期:2018-11-07 出版日期:2019-03-01 发布日期:2019-03-15
  • 通讯作者: 王爽 E-mail:wshuang@xjtu.edu.cn
  • 作者简介:杨宇轩,硕士,Email:dr. yangyx@qq.com
  • 基金资助:
    国家自然科学基金(81200822)

Biological function of amelogenin during periodontal regeneration

Yuxuan Yang,Haixia Zhang,Shuang Wang()   

  1. Dept. of Orthodontics, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
  • Received:2018-06-25 Revised:2018-11-07 Online:2019-03-01 Published:2019-03-15
  • Contact: Shuang Wang E-mail:wshuang@xjtu.edu.cn
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81200822)

摘要:

牙周组织缺损的修复是牙周治疗的一大难题,目前釉基质蛋白被广泛用于牙周组织再生治疗,并取得了良好的治疗效果。釉原蛋白是釉基质蛋白的主要成分,在牙周组织再生中发挥着多种生物学作用,调节牙周组织细胞的生物学行为,进而影响牙周组织再生的过程。目前对于釉原蛋白引起牙周组织再生的生物学机制仍不清楚,其作用的信号通路仍有待研究。本文将从调节细胞的黏附、迁移、增殖、分化等方面,论述釉原蛋白在牙周组织再生中的作用,探讨其可能的作用机制。

关键词: 釉原蛋白, 釉基质蛋白, 细胞黏附, 细胞迁移, 细胞增殖, 细胞分化

Abstract:

Recovery of the lost bone tissue of periodontitis patients is the ultimate purpose of periodontic clinical treatment. Enamel matrix proteins (EMPs) are widely used in periodontal regeneration treatment and lead to an appealing outcome. Amelogenin (AML) is the major component of EMPs with multiple biological effects on periodontal regeneration progress. However, the mechanism of this progress is still unclear. The signal pathway by which AML may be triggered during bone regeneration is still under investigation. In this study, we attempt to discuss the function of AML in cell attachment, migration, proliferation and differentiation during periodontal regeneration and try to explain possible mechanisms underlying such progress.

Key words: amelogenin, enamel matrix protein, cell attachment, cell migration, cell proliferation, cell differentiation

中图分类号: 

  • Q813

图 1

Grp78介导的细胞内吞作用"

图 2

Wnt/β-连环蛋白通路示意图"

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