国际口腔医学杂志

国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (1): 37-42.doi: 10.7518/gjkq.2019.01.007

• 综述 • 上一篇    下一篇

仿生多肽促进牙体硬组织再矿化的研究进展

陶思颖,梁坤能,李继遥()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科 成都 610041
  • 收稿日期:2018-05-10 修回日期:2018-10-03 出版日期:2019-01-01 发布日期:2019-01-11
  • 通讯作者: 李继遥
  • 作者简介:陶思颖,博士,Email：taosiying2021@qq.com
  • 基金资助:
    国家自然科学基金(81670977);四川省科技厅重点项目(2017SZ0030)

Research advances in biomimetic peptides promoting tooth remineralization

Siying Tao,Kunneng Liang,Jiyao Li()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-05-10 Revised:2018-10-03 Online:2019-01-01 Published:2019-01-11
  • Contact: Jiyao Li
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81670977);Key Program of Science and Technology Department of Sichuan Province(2017SZ0030)

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摘要：

牙体硬组织仿生再矿化是口腔医学和生物材料领域共同关注的热点问题,利用人体釉原蛋白、牙本质非胶原蛋白等有调控生物矿化功能的蛋白质氨基酸序列,设计仿生多肽材料,并诱导再矿化是促进牙体硬组织再生修复的新方法,本文就仿生多肽促进再矿化的理论基础及其代表性多肽的研究进展作一综述。

关键词: 仿生多肽, 牙体, 再矿化

Abstract:

Tooth biomimetic remineralization is a key issue in both oral medicine and biomaterial science. Tooth biomimetic remineralization induced by peptides designed from human proteins which can control biomineralization, such as ameloblastin and dentin non-collagenous proteins, is a new method of tooth regeneration. Basic theories of biomimetic peptides promoting remineralization and several representative peptides are reviewed in the paper.

Key words: biomimetic peptides, tooth, remineralization

中图分类号: 

  • R783.1
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