arginine,enamel,demineralization,remineralization,

An in vitro study of remineralization potential of several toothpastes on initial enamel lesions

Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (6): 710-713.doi: 10.3969/j.issn.1673-5749.2012.06.002

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An in vitro study of remineralization potential of several toothpastes on initial enamel lesions

Huang Yajing, Li Yueheng, Huang Rui, Qian Yingzi, Duan Yanxia, Zhou Zhi.   

  1. Dept． of Conservative Dentistry and Endodontics, The Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 401147, China
  • Received:2012-05-13 Revised:2012-07-12 Online:2012-11-01 Published:2012-11-01

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Abstract:

Objective To assess the remineralization property of several toothpastes on initial enamel lesions. Methods Bovine enamel blocks with in vitro produced initial lesion were used. The lesions were subjected to a pH-cycling regime for 12 d, with one of five treatments: NaF（positive control） group, pro-arginine group, casein phosphorylation of protein group, toothpaste with 0.11% fluoride group and with distilled and deionized water （DDW） group for negative control. The samples were subsequently evaluated using a microhardness tester, polarised light microscopy（PLM） and confocal laser scanning microscope（CLSM）. Results Surface hardness measurements revealed pro-arginine group, casein phosphorylation of protein group and NaF group had significantly greater effect on enhancing remineralization than that of toothpaste with 0.11% fluoride group（P<0.05）. Detailed investigation of PLM indicated that casein phosphorylation of protein group and toothpaste with 0.11% fluoride group had limited capacity to reduce the lesion depth compared with pro-arginine group and NaF group（P<0.05）. Comparing with toothpaste with 0.11% fluoride group , casein phosphorylation of protein group had a significantly greater property of limiting the lesion depth（P<0.05）. The results of CLSM inferred that the reduction of fluorescent dye infiltration in toothpaste with 0.11% fluoride group and casein phosphorylation of protein group was less than pro-arginine group and NaF group. Conclusion There is a significant synergistic effect of pro-arginine treatment on promoting the remineralization of initial enamel lesion compared with the other groups.

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