Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (4): 444-446.doi: 10.7518/gjkq.2013.04.007

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A preliminary clinical study of genotoxicity in oral mucosa cells exposed to Ni-Cr alloy

Lin Guofen, Chen Zhihong, Liu Li.   

  1. Dept. of Prosthodontics, Hospital of Stomatology, School of Medicine, Zhejiang University, Hangzhou 310006, China
  • Received:2012-12-27 Revised:2013-03-20 Online:2013-07-01 Published:2013-07-01

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Abstract:

Objective The aim of the study was to assess the genotoxicity in oral mucosa cells exposed to Ni-Cr alloy. Methods Sixty-eight subjects were divided into two groups, including 34 subjects of exposure group and 34 subjects of control group. The genotoxicity in oral mucosa cells were assessed by micronucleus assay. Micronuclei frequency（MNF） and micronucleated cell frequency（MCF） were calculated. Results Micronucleus assay revealed that the MNF and MCF of oral mucosa cells in exposure group were 1.63‰±2.03‰ and 1.26‰±1.42‰, while the MNF and MCF were 1.57‰±1.88‰ and 1.06‰±1.16‰ in control group respectively. There were no significant differences（P>0.05） between two groups. Conclusion The results suggested that there was no significant genotoxicity in oral mucosa exposed to Ni-Cr alloy by micronucleus assay.

Key words: Ni-Cr alloy, micronuclei frequency, micronucleated cell frequency, micronucleus assay, genotoxicity


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