Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (4): 553-556.doi: 10.7518/gjkq.2013.04.041

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P300/cyclic adenosine monophosphate response element binding protein and its biological functions

Wang Tong, Xu Qiong.   

  1. Dept. of Conservative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2012-08-01 Revised:2013-03-19 Online:2013-07-01 Published:2013-07-01

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Abstract:

P300 and cyclic adenosine monophosphate response element binding protein（CBP） were originally identified as transcriptional co-activator proteins that bind to the adenoviral E1A and the cyclic adenosine monophosphate- response element binding protein, respectively. They play a central role in multiple physiological events, for example, cell proliferation, differentiation and apoptosis. The transcription regulating properties of P300/CBP appear to be exerted through multiple mechanisms. This article intended to give a review on the structures, functions and mechanisms of P300/CBP, and its effects on transcription factors and cell cycle-associated factors.

Key words: P300, cyclic adenosine monophosphate response element binding protein, transcriptional factor, transcriptional co-activator, acetyltransferase


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