Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (5): 644-654.doi: 10.7518/gjkq.2025093

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Research progress on the regulatory mechanism and prevention and treatment of proanthocyanidins in oral diseases

Xing Wu1,2(),Yuping Liu1,Yifan Zhang1,Yucong Xia1,Zhaohe Li1,Xiaowei Yi1,Hong Xia1(),Wenwen Ding1   

  1. 1.Dept. of Medicine, Jingchu University of Technology, Jingmen 448001, China
    2.School of Stomatology, Zhejiang Chinese Medicine University, Hangzhou 310059, China
  • Received:2024-09-06 Revised:2024-10-31 Online:2025-09-01 Published:2025-08-27
  • Contact: Hong Xia E-mail:wuxing2062@163.com;xiahongvip@163.com
  • Supported by:
    Science Research Program of the Education Department of Hubei Province(D20224301);Open Project of Hubei Engineering Research Center for Special Flower Biological Breeding(2023YB003);Innovation and Entrepreneurship Program for College Students of Hubei Province(S202311336023)

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Abstract:

Proanthocyanidins (PCs), a class of natural compounds with strong antioxidant properties and diverse biolo-gical activities, demonstrate significant potential in the prevention and treatment of oral diseases. They effectively promote the remineralization of dental hard tissues, inhibit the development of dental plaque biofilms, suppress the proliferation of oral cancer cells, and provide beneficial effects in the treatment of oral mucosal diseases. This review highlights that the core advantage of PCs in managing oral diseases stems from their dual-action mechanism: they not only target and inhibit pathogenic biofilms but also modulate the host’s oxidative stress and inflammatory responses. Notably, PCs interfere with microbial adhesion and biofilm formation via a non-bactericidal pathway, offering a novel strategy to potentially address microbial drug resistance. Although most current research is confined to the laboratory stage, the safety and multipotency of PCs position them as a promising natural adjuvant for oral disease therapy. This review systema-tically summarizes the applications of PCs in prevalent oral diseases and elucidates their biological mechanisms, aiming to establish a scientific basis for future clinical translation.

Key words: procyanidins, oral diseases, immune regulation, prevention and treatment of diseases

CLC Number: 

  • R78

TrendMD: 

Fig 1

Chemical structures of type A PC (left) and type B PC (right)"

Fig 2

The biological activity of PC on common oral diseases"

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