Int J Stomatol

Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (2): 177-180.doi: 10.3969/j.issn.1673-5749.2011.02.014

Previous Articles     Next Articles

Research progress on the anti-tumor activity of beta-defensins and its correlation with oral carcinoma

LI Yan-zhong, DAN Hong-xia, LIU Na, CHEN Qian-ming, ZENG Xin.   

  1. Dept. of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2010-04-06 Revised:2010-10-30 Online:2011-03-20 Published:2011-03-20

RichHTML

2

PDF (PC)

845

Abstract:

Defensins are a class of cationic peptides which is widely found in plants and animals, and are a representative sub-clan of antimicrobial peptides family（Antimicrobial peptides are a kind of short-chain peptide of broad-spectrum antimicrobial effects） and a very conservative host defense molecules. So far, a variety of defensins have been found. Human beta defensin（hBD）play an important role in these defensins, and have a strong bactericidal activity, chemotactic activity, regulatory function of phagocytic cells and acquired immune etc. In addition, several researches also found that hBD have an anti-tumor activity, and are closely related with oral carcinoma. Therefore, hBD may provide a new strategy for the prevention and treatment of the tumor.

Key words: beta-defensin, anti-tumor activity, oral carcinoma


TrendMD: 
[1] Gu Qianping, Meng Jian, Meng Qingfei, Zhang Jie, Li Zhiping.. Clinical study on Nimotuzumab combined with Docetaxel-Cisplatin-Fluorouracil regimen in the treatment of advanced oral carcinoma [J]. Inter J Stomatol, 2011, 38(6): 652-655.
[2] MENG Xian- rui, LIU Jin- zhong. Ear ly diagnosis of or al car cinoma [J]. Inter J Stomatol, 2008, 35(3): 329-329～331.
[3] ZHENG Yan- li，LIU Jin- zhong.. Establishment of Animal Model of Or al Carcinoma [J]. Inter J Stomatol, 2007, 34(02): 112-115.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .