Abstract: The eruption of tooth is a complex physiological phenomenon which is regulated strictly. The tooth eruption needs to form a sprouts the channel which is made by the mature osteoclast to the alveolar bone of the occlusal surface of tooth germ. The osteoprotegerin and receptor activator nualear factor - κB ligand and receptor activator nualear factor- κB system may adjust the metabolism by the adjustment to osteoclast. Macrophage colonystimulating factor- 1 and parathyroid hormone related protein may improve the pression of RANKL protein to regulate the differentiation and activation of osteoclast, which can guarantee normal absorpted of the alveolar bone when tooth eruption.