Int J Stomatol

Int J Stomatol ›› 2026, Vol. 53 ›› Issue (6): 884-894.doi: 10.7518/gjkq.2026614

• Review • Previous Articles    

Neuroimmunology in the progression of salivary adenoid cystic carcinoma

Jiarong Wang(),Yaling Tang()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2025-04-14 Revised:2026-02-25 Online:2026-11-01 Published:2026-10-29
  • Contact: Yaling Tang E-mail:wjr202427@163.com;tangyaling@scu.edu.cn
  • Supported by:
    Clinical Research Program of West China Hospital of Stomatology, Sichuan University(LCYJ-MS-202308)

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Abstract:

Salivary adenoid cystic carcinoma (SACC) is a common malignant salivary gland tumor characterized by its propensity for perineural invasion and poor prognosis in advanced stages. Recent advancements in neuroimmunology have highlighted the remarkably role of neural-immune interactions in tumor regulation. However, the specific neuroimmunological mechanisms underlying SACC remain to be elucidated. This review aims to summarize potential neuroimmunological mechanisms in SACC by examining the interactions between neural and immune cells and the roles of neural and immune factors, thereby identifying potential therapeutic targets for future research.

Key words: neuroimmunology, salivary adenoid cystic carcinoma, perineural invasion, tumor microenvironment, Schwann cells

CLC Number: 

  • R739.87

TrendMD: 

Fig 1

Selected immunomodulatory mechanisms of SCs in the tumor microenvironment"

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