Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (5): 691-698.doi: 10.7518/gjkq.2025094

• Reviews • Previous Articles    

Yes-associated protein as a mechanotransduction effector molecule in the occurrence and development of nonneoplastic diseases in oral and other systems

Lili Xue1(),Shuai Chen2,Bing Yan2()   

  1. 1.Dept. of Stomatology, the First Affiliated Hospital of Xiamen Univerisity, Xiamen 361001, China
    2.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-08-02 Revised:2024-10-20 Online:2025-09-01 Published:2025-08-27
  • Contact: Bing Yan E-mail:174892334@qq.com;yanbing_west@163.com
  • Supported by:
    Natural Science Foundation of Fujian Province(2021J05288)

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Abstract:

Yes-associated protein (YAP) is a transcriptional coactivator that regulates the expression of target genes after binding with related transcription factors in the nucleus through classical Hippo or non-Hippo pathways. Hence, it directly participates in cell metabolism and maintains the dynamic balance of cell proliferation and apoptosis. Previous research on YAP mostly focused on neoplastic diseases. In recent years, increasing studies have been conducted on YAP as an extracellular mechanoreceptor in nonneoplastic diseases. This work reviews the molecular mechanism of YAP in nonneoplastic diseases (oral and other systemic diseases) to further understand its role and provide new ideas and strategies for future clinical treatment of related diseases.

Key words: Yes-associated protein, Hippo pathway, non-neoplastic diseases, molecular mechanism

CLC Number: 

  • Q257

TrendMD: 

Fig 1

Mechanical stress from the extracellular environment influences the expression of YAP protein through signal transduction pathways"

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