Int J Stomatol

Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (4): 403-406.doi: 10.3969/j.issn.1673-5749.2011.04.009

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Study on collagen membrane as growth factors delivery carrier materials to accelerate mandibular fracture healing

Chen Jianlin1, Yang Zhe1, Tang Yanfeng2，3, Hu Xueqing1, Zhang Jizhong1, Zhou Ye1, Zheng Xiaohui2.   

  1. 1. Dept. of Stomatology, Lingwu People’s Hospital of Muslim Population Autonomous Region in Ningxia, Lingwu 750400, China; 2. Dept. of Traumatic and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; 3. Dept. of Stomatology, Baotou Central Hospital in Mongolia Autonomous Region, Baotou 014040, China
  • Received:2011-01-24 Revised:2011-04-22 Online:2011-07-20 Published:2011-07-20

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Abstract:

Objective To explore the possibility of collagen membrane to accelerate mandibular fracture healing. Methods 12 New Zealand rabbits were randomly divided into two groups, the mandibular fracture model on both sides were prepared. Left was rb -bFGF/rhBMP -2/collagen membrane as experimental group, and right was the control group. Hematoxylin-eosin（HE） staining, Masson staining and India ink staining were taken at the 2, 4, 12 weeks after surgery. Results HE and Masson staining showed: After 2 weeks, more fibrous tissue and blood vessels were seen between the fracture ends in the experimental group than the control group. There were some fibrous cartilages forming in the edge of the fracture ends in the experimental group. After 4 weeks, fibrous fracture callus were seen in the fracture gap in the experimental group. The ingrowths of fibrous tissue and blood vessels were seen in the control group. After 12 weeks, bone healings were seen in both groups. The bony trabecular directions were tidier in the experimental group than in the control group. India ink staining showed: After 2 weeks and 4 weeks, the vascular densities in the experimental group were significantly more than in the control group. There was little difference between the two groups after 12 weeks. Conclusion rb-bFGF/rhBMP-2/collagen membrane could accelerate fracture healing.

Key words: mandibular fracture, basic fibroblast growth factor, bone morphogenetic protein -2, fracture healing, collagen membrane


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