关键词: c-Jun N-末端激酶, 细胞迁移, 信号转导

Abstract:

C-Jun N-terminal kinase(JNK) is a member of the mitogen-activated protein kinase family, which regulates diverse cellular programs by relaying extracellular signals to intracellular responses. Activated primarily by cytokines and environmental stress, the JNK signal transduction pathway regulates cell migration and plays an important role in cellular proliferation, differentiation, inflammatory response, and apoptosis. The mechanism of cell migration is closely related to the cytoskeleton, focal adhesion, focal adhesion kinase, integrin, and ras homology oncogene family proteins, G-protein, and aquaporin. Recent research on JNK pathway regulating cell migration shows that the activation of the JNK signaling pathway can promote epithelial cell and fibroblast migration and can enhance wound healing and tissue repair. Inhibiting the JNK signaling pathway can reduce cell migration and invasion in tumor cells. The function and mechanism of JNK in inflammation are controversial. Discovering the specific mechanisms underlying the activities of the JNK signal transduction pathway, which is involved in regulating cell migration, can provide new ideas for tissue repair, inflammation control, and tumor treatment.

Key words: c-Jun N-terminal kinase, cell migration, signal transduction