国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (5): 691-698.doi: 10.7518/gjkq.2025094

• 综述 • 上一篇    

Yes相关蛋白作为机械传导效应分子在口腔及其他系统非肿瘤性疾病发生发展中的作用

薛丽丽1(),陈帅2,闫冰2()   

  1. 1.厦门大学附属第一医院口腔科 厦门 361001
    2.口腔疾病防治全国重点实验室;国家口腔医学中心 国家口腔疾病临床医学研究中心;四川大学华西口腔医院头颈肿瘤外科 成都 610041
  • 收稿日期:2024-08-02 修回日期:2024-10-20 出版日期:2025-09-01 发布日期:2025-08-27
  • 通讯作者: 闫冰
  • 作者简介:薛丽丽，副主任医师，博士，Email：174892334@qq.com
  • 基金资助:
    福建省自然科学基金(2021J05288)

Yes-associated protein as a mechanotransduction effector molecule in the occurrence and development of nonneoplastic diseases in oral and other systems

Lili Xue1(),Shuai Chen2,Bing Yan2()   

  1. 1.Dept. of Stomatology, the First Affiliated Hospital of Xiamen Univerisity, Xiamen 361001, China
    2.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-08-02 Revised:2024-10-20 Online:2025-09-01 Published:2025-08-27
  • Contact: Bing Yan
  • Supported by:
    Natural Science Foundation of Fujian Province(2021J05288)

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摘要：

Yes相关蛋白（YAP）是一种转录共激活因子，可通过经典Hippo通路或非Hippo通路与细胞核内相关转录因子结合后调节靶基因的表达，以直接参与细胞的新陈代谢及维持细胞增殖与凋亡的动态平衡等过程中。研究表明，目前关于YAP的研究多集中在肿瘤相关性疾病的发生发展中，近年来，关于YAP作为细胞外机械传导效应分子调控非肿瘤性疾病的研究逐渐增多，本文对YAP在非肿瘤性疾病（口腔及其他系统性疾病）中的分子机制作一综述，以求进一步了解YAP在非肿瘤性疾病的中作用，为未来临床治疗相关疾病研究提供新的思路及策略。

关键词: Yes相关蛋白, Hippo信号通路, 非肿瘤性疾病, 分子机制

Abstract:

Yes-associated protein (YAP) is a transcriptional coactivator that regulates the expression of target genes after binding with related transcription factors in the nucleus through classical Hippo or non-Hippo pathways. Hence, it directly participates in cell metabolism and maintains the dynamic balance of cell proliferation and apoptosis. Previous research on YAP mostly focused on neoplastic diseases. In recent years, increasing studies have been conducted on YAP as an extracellular mechanoreceptor in nonneoplastic diseases. This work reviews the molecular mechanism of YAP in nonneoplastic diseases (oral and other systemic diseases) to further understand its role and provide new ideas and strategies for future clinical treatment of related diseases.

Key words: Yes-associated protein, Hippo pathway, non-neoplastic diseases, molecular mechanism

中图分类号: 

  • Q257

图1

细胞外机械应力通过信号调节通路影响YAP蛋白的表达"

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