国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (3): 263-269.doi: 10.7518/gjkq.2019034

• 信号通路专栏 • 上一篇    下一篇

Hippo信号通路在骨代谢中的研究进展

张歆缘,王斌,于晖,朱丽文,向琳()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院种植科 成都 610041
  • 收稿日期:2018-05-22 修回日期:2019-01-16 出版日期:2019-05-01 发布日期:2019-06-05
  • 通讯作者: 向琳 E-mail:dentistxiang@126.com
  • 作者简介:张歆缘,学士,Email:Ninazhang950411@163.com
  • 基金资助:
    国家自然科学基金(81701007);四川省科技计划项目(2018RZ0087);中央高校基本科研业务费专项资金(2017SCU12056);中央高校基本科研业务费专项资金(2018SCUH0006);中国博士后科学基金(2018M631091);四川大学华西口腔医院青年科学研究基金项目(2016-11)

Research progress on role of Hippo pathway in bone metabolism

Xinyuan Zhang,Bin Wang,Hui Yu,Liwen Zhu,Lin Xiang()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2018-05-22 Revised:2019-01-16 Online:2019-05-01 Published:2019-06-05
  • Contact: Lin Xiang E-mail:dentistxiang@126.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81701007);Sichuan Science and Technology Program(2018RZ0087);Fundamental Research Funds for the Central Universities(2017SCU12056);Fundamental Research Funds for the Central Universities(2018SCUH0006);China Postdoctoral Science Foundation(2018M631091);Youth Science Foundation of West China Hospital of Stomatology of Sichuan University(2016-11)

摘要:

在哺乳动物中,Hippo信号通路具有高度保守性,其在调节骨代谢、维持骨骼正常生理功能方面有重要作用。哺乳动物sterile 20样激酶(MST)1/2、大肿瘤抑制因子(LATS)1/2和Yes相关蛋白(YAP)/携带PDZ结合基序的转录辅助激活物(TAZ)为Hippo信号通路核心组件,在其上下游多种转录因子的介导下,Hippo信号通路调控成骨细胞、破骨细胞、软骨细胞等细胞的生理活动。本文就Hippo信号通路在骨代谢中的研究进展进行综述,为骨代谢相关疾病的研究和治疗提供可能的思路和策略。

关键词: Hippo信号通路, 哺乳动物sterile 20样激酶, Yes相关蛋白, 骨代谢

Abstract:

In mammals, the Hippo signalling pathway is highly conserved and regulates bone metabolism and maintains the essential physiological functions of bones. Mammalian sterile 20-like kinase 1/2, large tumour suppressor 1/2 and the Yes-associated protein/transcriptional coactivator with PDZ-binding motif are the core components of the Hippo signalling pathway. This pathway mediates the physiological functions of osteoblasts, osteoclasts and chondrocytes under the regulation of multiple transcription factors upstream and downstream. In this study, we highlight the recent research progress on the mechanism underlying bone metabolism in the Hippo signalling pathway. We hope that this review can provide new ideas and strategies for further investigations and treatment of bone metabolism-related diseases.

Key words: Hippo signaling pathway, mammalian sterile 20-like kinase, Yes associated protein, bone metabolism

中图分类号: 

  • Q257
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