国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (3): 258-262.doi: 10.7518/gjkq.2019033

• 信号通路专栏 • 上一篇    下一篇

骨形态发生蛋白信号通路及其交叉对话对下颌骨发育的影响

王小萌1,王晓1,史册2,3,孙宏晨2,3,黄洋1()   

  1. 1.吉林大学口腔医院儿童口腔科 长春 130021
    2.吉林大学口腔医院口腔病理科 长春 130021
    3.吉林省牙发育及颌骨重塑与再生重点实验室 长春 130021
  • 收稿日期:2018-04-20 修回日期:2019-01-08 出版日期:2019-05-01 发布日期:2019-06-05
  • 通讯作者: 黄洋 E-mail:huangyang1960@163.com
  • 作者简介:王小萌,硕士,Email:18324614381@163.com

Effects of bone morphogenetic protein signalling pathway and its crosstalks on mandible development

Xiaomeng Wang1,Xiao Wang1,Ce Shi2,3,Hongchen Sun2,3,Yang Huang1()   

  1. 1.Dept. of Pediatric Dentistry, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2.Dept. of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun 130021, China
    3.Key Laboratory of Tooth Development and Bone Remodeling of Jilin Province, Changchun 130021, China
  • Received:2018-04-20 Revised:2019-01-08 Online:2019-05-01 Published:2019-06-05
  • Contact: Yang Huang E-mail:huangyang1960@163.com

摘要:

下颌骨是颅面部唯一能自主活动的骨,可发挥咀嚼、发音和吞咽等多种重要功能。骨形态发生蛋白(BMP)信号通路在骨和软骨的形成及稳态维持中起到重要作用,对下颌骨的发育是不可或缺的。已知BMP信号通路的配体、受体及其下游多种细胞因子与其他信号通路相关联,组成一个复杂且庞大的信号网络,共同调节下颌骨的发育。本文主要介绍BMP信号通路以及与BMP信号通路交叉对话的信号通路在下颌骨发育中的作用。

关键词: 骨形态发生蛋白信号通路, 交叉对话, 下颌骨发育

Abstract:

Mandible, as the only autonomic movable bone in the craniofacial region, plays multiple important roles, such as chewing, pronunciation and swallowing. Bone morphogenetic protein (BMP) signalling pathway plays a fundamental role in the formation and homeostasis of bone and cartilage and is essential for mandible development. BMP ligands, receptors and downstream cytokines are associated with other signalling pathways, thereby forming a complex and extensive signalling network which regulates mandibular development. This review mainly introduces the roles of BMP signalling and its crosstalks during mandible development.

Key words: bone morphogenetic protein signalling pathway, crosstalk, mandible development

中图分类号: 

  • Q257
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