国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (4): 442-449.doi: 10.7518/gjkq.2019032

• 综述 • 上一篇    下一篇

脾酪氨酸激酶及其相关信号通路对头颈部肿瘤发生与发展的影响及作用机制

岳史婧1,卿艺凡1,林洁2,韩波1()   

  1. 1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院头颈肿瘤外科 成都 610041
    2. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院麻醉科 成都 610041
  • 收稿日期:2018-08-23 修回日期:2019-01-15 出版日期:2019-07-10 发布日期:2019-07-12
  • 作者简介:岳史婧,学士,Email: Yshijing@163.com
  • 基金资助:
    四川省科学技术厅科技支撑计划项目(2016SZ0063);四川省卫生和计划生育委员会科研课题(17PJ535)

Effects of spleen tyrosine kinase and its related signalling pathways on the development of head and neck tumors and their mechanisms

Yue Shijing1,Qing Yifan1,Lin Jie2,Han Bo1()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Anesthology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
  • Received:2018-08-23 Revised:2019-01-15 Online:2019-07-10 Published:2019-07-12
  • Supported by:
    This study was supported by Science and Technology Support Program of Sichuan Science and Technology Department(2016SZ0063);Health Bureau of of Sichuan Health and Family Planning Commission(17PJ535)

摘要:

脾酪氨酸激酶(Syk)对细胞的信号转导有广泛的作用,具有调节细胞应答与促进细胞激活、增殖与分化、吞噬等作用。在对颈部肿瘤的研究中,Syk的异常表达和活性降低可通过多种信号通路影响肿瘤细胞的增殖、凋亡、侵袭、转移等多个方面,Syk及其相关信号通路可能成为靶向治疗头颈部肿瘤的有效靶点,具有良好的临床应用潜力。本文旨在总结Syk及其相关信号通路对头颈部肿瘤发生、发展的影响,以及这些影响的细胞内机制,展望Syk及其相关信号通路作为靶点在临床应用中的前景。

关键词: 脾酪氨酸激酶, 头颈部肿瘤, 信号通路

Abstract:

Spleen tyrosine kinase (Syk) has a wide range of effects on cell signal transduction, regulating cellular responses and promoting cell activation, proliferation, differentiation, and phagocytosis. In the studies on head and neck tumors, the abnormal expression and the reduced activity of Syk can affect the proliferation, apoptosis, invasion and metastasis of tumor cells via various signalling pathways. Syk and its related signalling pathways can be potential targets for clinical treatment of head and neck tumors. This review aims to summarize the effects of Syk and its related signalling pathways on the development of head and neck tumors and its intracellular mechanisms, and thus to evaluate their potential application in clinic.

Key words: spleen tyrosine kinase, head and neck tumor, signalling pathway

中图分类号: 

  • Q257

图 1

IL-6激活鳞状细胞癌细胞内Syk信号通路模式图"

图 2

Syk激活人口腔鳞状细胞癌细胞内ERK1/2和mTOR信号通路模式图"

图 3

Syk协同GRB2信号通路激活PI3K/AKT和PLCγ信号通路模式图"

图 4

Syk在巨噬细胞中的作用模式图"

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