国际口腔医学杂志 ›› 2019, Vol. 46 ›› Issue (4): 450-455.doi: 10.7518/gjkq.2019031

• 综述 • 上一篇    下一篇

NLRP3炎性小体在牙周疾病中的研究进展

朱博文1,陈立妹1,郭竹玲1,2()   

  1. 1. 海南医学院口腔医学院 海口 570100
    2. 海南医学院第一附属医院口腔科 海口 570100
  • 收稿日期:2018-04-08 修回日期:2019-01-02 出版日期:2019-07-01 发布日期:2019-07-12
  • 作者简介:朱博文,学士,Email: 841962263@qq.com
  • 基金资助:
    海南省自然科学基金(817330);海南省高等学校科学研究项目(Hnky2017-31);海南省青年科技英才学术创新计划项目(QCXM201817);海南医学院第一附属医院青年培育基金项目(HYFYPY201702);海南医学院课程建设专项项目(HYJW201834)

Review of NLRP3 inflammasomes in periodontal diseases

Zhu Bowen1,Chen Limei1,Guo Zhuling1,2()   

  1. 1. School of Stomatology, Hainan Medical University, Haikou 570100, China
    2. Dept. of Stomatology, The First Affiliated Hospital of Hainan Medical University, Haikou 570100, China
  • Received:2018-04-08 Revised:2019-01-02 Online:2019-07-01 Published:2019-07-12
  • Supported by:
    This study was supported by Hainan Provincial Natural Science Foundation(817330);Scientific Research Projects of Higher Education Institutions in Hainan Province(Hnky2017-31);Young Talents’ Science and Technology Innovation Project of Hainan Association for Science and Technology(QCXM201817);Youth Development Fund Project of the First Affiliated Hospital of Hainan Medical University(HYFYPY201702);Course Construction Project of Hainan Medical University(HYJW201834)

摘要:

牙周病被认为是微生物感染与宿主免疫、炎症反应共同导致的结果。NLRP3炎性小体与牙周疾病的发生、发展存在关联已被证实,其在牙周疾病中出现活化与抑制两种状态也得到越来越多学者的重视。在牙周病进程中,NLRP3炎性小体活化与抑制状态的触发条件与切换过程尚未形成定论,对于NLRP3相关基因多态性与基因突变在牙周疾病中的研究也刚刚起步。本文主要对NLRP3炎性小体的活化假说、抑制机制及其在牙周疾病中的作用进行综述。

关键词: NLRP3, 炎性小体, 牙周疾病, 免疫炎性反应

Abstract:

Periodontal disease is considered as the joint effort of microbial infection and immunoinflammatory responses. The association between NLRP3 inflammasome and periodontal disease has been confirmed in many experiments. The reverse states, activation and inhibition of NLRP3 inflammasome have received increasing attention. In the progress of periodontal disease, the explanations for the activation and inhibition of the NLRP3 inflammasome have not been unified with the triggering conditions and the switching process. Studies on NLRP3 inflammasome gene mutation or gene polymorphism in periodontal disease have just been initiated. This article briefly describes the NLRP3 inflammasome and highlights the currently accepted hypothesis of the activation of this oligomer and the finding regarding various inhibitory mechanisms.

Key words: NLRP3, inflammasome, periodontal disease, immunoinflammatory responses

中图分类号: 

  • R781.4

图 1

NLRP3炎性小体的组成和组装"

图 2

NLRP3炎性小体的信号传导模型"

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