国际口腔医学杂志

国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (3): 318-324.doi: 10.7518/gjkq.2016.03.015

• 综述 • 上一篇    下一篇

表观遗传在牙发生和牙再生中的作用及意义

周晨1,凌均棨2   

  1. 1.中山大学光华口腔医学院?附属口腔医院正畸科 广东省口腔医学重点实验室 广州 510055;2.中山大学光华口腔医学院?附属口腔医院牙体牙髓病科 广东省口腔医学重点实验室 广州 510055
  • 收稿日期:2015-06-30 修回日期:2016-02-23 出版日期:2016-05-01 发布日期:2016-05-01
  • 通讯作者: 凌均棨，教授，博士，Email：lingjq@mail.sysu.edu.cn
  • 作者简介:周晨，博士，Email：zhouchen@mail2.sysu.edu.cn
  • 基金资助:
    国家自然科学基金（81170932）；广东省领军人才专项经费（52000-3210002）

Epigenetics in tooth development and its implication in tooth regeneration

Zhou Chen1, Ling Junqi2   

  1. 1. Dept. of Orthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China; 2. Dept. of Conservative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China) This study was supported by the National Natural Science Foundation of China(81170932)and Special Talents Fund in Guangdong Province(52000-3210002).
  • Received:2015-06-30 Revised:2016-02-23 Online:2016-05-01 Published:2016-05-01

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摘要： 表观遗传是指DNA序列不发生变化，基因表达却发生了可遗传改变的一种遗传方式，主要涉及DNA甲基化和组蛋白的不同翻译后修饰，决定了特定的基因表达形式。DNA甲基化常引起基因表达抑制，而脱甲基化则引起基因表达开放。组蛋白有众多的共价修饰形式，根据修饰的种类、位点及个数的不同，引起基因沉默或激活。表观遗传修饰是细胞定向分化和重编程中基因特异性表达的重要调控方式，在机体发生中扮演着重要的角色。在牙发生过程中，表观遗传与传统的基因表达调控协同，调节细胞增殖、分化和迁移相关基因的时空表达，最后导致牙的形成。诠释牙发生过程中的表观遗传调控机制，无疑可为牙再生提供关键的线索和思路。

关键词: 牙发育, 基因表达调控, 表观遗传, 牙再生, 牙发育, 基因表达调控, 表观遗传, 牙再生

Abstract: Epigenetics, mainly including DNA methylation and histone post-translational modification, is the heritable changes that are not caused by changes in the DNA sequence; this change also alters how genes are expressed. DNA methylation typically causes gene transcriptional silencing, whereas demethylation leads to transcription activation. A large number of covalent modifications on histone, such as different types, residues, and amount, will affect the inhibition or activation of gene expression. Epigenetic modifications play pivotal roles in organogenesis by controlling gene expression during cell fate determination and reprogramming. In the process of tooth development, complex orchestration between genetic and epigenetic programs regulates the spatiotemporal expression of cell proliferation-, differentiation-, and migration-related genes, and finally tooth formation. Exploring the molecular biology of epigenetic, together with the epigenetic findings in tooth development, is not only fundamental but also inspiring for tooth regeneration.

Key words: tooth development, gene expression and regulation, epigenetics, tooth regeneration, tooth development, gene expression and regulation, epigenetics, tooth regeneration

中图分类号: 

  • Q 786
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