Int J Stomatol

Int J Stomatol ›› 2026, Vol. 53 ›› Issue (6): 936-944.doi: 10.7518/gjkq.2026139

• Review • Previous Articles    

Research advances in micro-arc oxidation-modified titanium alloy dental materials

Beibei Zheng1,2(),Jianping Ren1,2()   

  1. 1.Teaching and Research Office of Mold Design and Manufacturing, School of Mechanical and Electrical Engineering and Mold Engineering, Taizhou Vocational College of Science & Technology, Taizhou 318020, China
    2.Key Laboratory of Mold Intelligent Manufacturing of Taizhou, Taizhou 318020, China
  • Received:2025-11-28 Revised:2026-08-12 Online:2026-11-01 Published:2026-10-29
  • Contact: Jianping Ren E-mail:laobei007@foxmail.com;renlinbo411@163.com
  • Supported by:
    2023 Taizhou City Second Batch of Industrial Science and Technology Program Projects(23gyb28)

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Abstract:

Titanium alloys are widely used in dental implants because of their excellent comprehensive properties, but they still encounter issues such as long osseointegration period, limited local biocompatibility, and potential corrosion. Micro-arc oxidation (MAO) technology can effectively improve the surface characteristics of titanium alloy via the electrochemical in-situ generation of a ceramic film layer. In this paper, the research progress in the application of MAO-modified titanium alloy dental materials was reviewed from four aspects: improvement of antibacterial properties through do-ping, promotion of bone integration ability and bioactivity, optimization of surface morphology and performance, and evaluation of clinical application potential and safety. MAO technology has the potential for multifunctional integration due to the in-situ generation of ceramic oxide films, combined with its antibacterial and bone integration promotion capabilities. Compared with anodic oxidation, plasma spraying, and other technologies, MAO demonstrates superior bonding strength and biological activity. In the future, multiple composite coating technologies must be developed to facilitate multifunctional integration. MAO technology provides a novel pathway for the development of high-performance dental implant materials.

Key words: micro-arc oxidation, titanium alloys, dental materials, antibacterial properties, surface morphology control, performance optimization, bone integration, clinical safety, element doping, nanoparticle coatings

CLC Number: 

  • R783.1

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Tab 1

Comparison of effects of various elements doped micro-arc oxidation coatings"

元素抗菌强度抗菌谱骨整合性

细胞毒性

风险

环境风险
Ag★★★★★广谱中等中（高剂量）高（纳米粒子释放）
Cu★★★★广谱高中（高剂量）低
Zn★★★中谱高低低
Sr★★窄谱极高极低无
Bi★★★中谱中等中（高剂量）中
Ga★★★★窄谱中等低低
[1] 都曼别克·阿曼台, 王思凡, 何惠宇. 种植体表面改性研究新进展[J]. 临床医学进展, 2024, 14(1): 1483-1489.
Amantai D, Wang SF, He HY. New research pro-gress in implant surface modification[J]. Adv Clin Med, 2024, 14(1): 1483-1489.
[2] Vijintanawan S, Boonsiriseth K, Bhattarai BP, et al. Titanium particle exfoliation from different dental implants after insertion[J]. Arch Orofac Sci, 2020, 15(2): 149-158.
[3] Țap MD, Stanciu Neculau C, Popescu G, et al. Disruptive technologies for learning and further investigation of the potential toxicity produced by titanium in the human body during the COVID-19 pandemic period[J]. Toxics, 2023, 11(6): 523.
[4] Romanos GE, Fischer GA, Delgado-Ruiz R. Tita-nium wear of dental implants from placement, under loading and maintenance protocols[J]. Int J Mol Sci, 2021, 22(3): 1067.
[5] Hoque ME, Showva NN, Ahmed M, et al. Titanium and titanium alloys in dentistry: current trends, recent developments, and future prospects[J]. Heliyon, 2022, 8(11): e11300.
[6] 李新芽. 钛合金等离子喷涂Al2O3-13wt.%TiO2涂层制备及摩擦学性能研究[D]. 镇江: 江苏大学, 2019.
Li XY. Fabrication of plasma sprayed Al2O3-13wt.%TiO2 coating on titanium alloy and its tribological properties[D]. Zhenjiang: Jiangsu Univ, 2019.
[7] 蒋璐. 影响钛种植体植入过程中表面钛颗粒脱落因素的初探研究[D]. 杭州: 浙江中医药大学, 2023.
Jiang L. Preliminary study on the factors affection the titanium particles shedding on the surface of titanium implants during implantation[D]. Hangzhou: Zhejiang Chinese Medical University, 2023.
[8] 高岩, 林曦, 刘影. 碱热处理纯钛表面纳米改性后对成骨细胞早期黏附生长的影响[J]. 中国组织工程研究, 2024, 28(15): 2302-2306.
Gao Y, Lin X, Liu Y. Effect of nano-modified tita-nium surface with alkali heat treatment on early adhesion and growth of osteoblasts[J]. Chin J Tissue Eng Res, 2024, 28(15): 2302-2306.
[9] 郭宇强. 碱液环境下钛合金表面阳极氧化改性及其经皮骨内固定植入试验研究[D]. 成都: 四川大学, 2021.
Guo YQ. Experimental study on the titanium alloy surface subjected to anodic oxidation in alkaline solution and its percutaneous bone internal fixation implantation[D]. Chengdu: Sichuan University, 2021.
[10] Dong YT, Liu ZY, Ma GF. The research progress on micro-arc oxidation of aluminum alloy[J]. IOP Conf Ser Mater Sci Eng, 2020, 729(1): 012055.
[11] Wen XY, Liu Y, Xi FQ, et al. Micro-arc oxidation (MAO) and its potential for improving the performance of titanium implants in biomedical applications[J]. Front Bioeng Biotechnol, 2023, 11: 128- 2590.
[12] Shimabukuro M. Antibacterial property and biocompatibility of silver, copper, and zinc in titanium dio-xide layers incorporated by one-step micro-arc oxidation: a review[J]. Antibiotics (Basel), 2020, 9(10): 716.
[13] Akshaya S, Rowlo PK, Dukle A, et al. Antibacterial coatings for titanium implants: recent trends and future perspectives[J]. Antibiotics (Basel), 2022, 11(12): 1719.
[14] Bakitian FA. A comprehensive review of the contemporary methods for enhancing osseointegration and the antimicrobial properties of titanium dental implants[J]. Cureus, 2024, 16(9): e68720.
[15] Cardoso GC, Barbaro K, Kuroda PAB, et al. Antimicrobial Cu-doped TiO2 coatings on the β Ti-30Nb-5Mo alloy by micro-arc oxidation[J]. Materials (Basel), 2023, 17(1): 156.
[16] 卢雪芹. 微弧氧化法制备的含铜TiO2陶瓷膜的微观结构演化与性能研究[D]. 武汉: 华中科技大学, 2021.
Lu XQ. Study on the microstructure evolution and performance of copper-containing TiO2 ceramic coating prepared by micro-arc oxidation[D]. Wuhan: Huazhong University of Science Technology, 2021.
[17] Negut I, Albu C, Bita B. Advances in antimicrobial coatings for preventing infections of head-related implantable medical devices[J]. Coatings, 2024, 14(3): 256.
[18] Kang BB, Lan DM, Yao C, et al. Evaluation of antibacterial property and biocompatibility of Cu doped TiO2 coated implant prepared by micro-arc oxidation[J]. Front Bioeng Biotechnol, 2022, 10: 941109.
[19] Woźniak-Budych MJ, Staszak K, Staszak M. Copper and copper-based nanoparticles in medicine-perspectives and challenges[J]. Molecules, 2023, 28(18): 6687.
[20] Pierre C, Bertrand G, Pavy I, et al. Antibacterial electrodeposited copper-doped calcium phosphate coatings for dental implants[J]. J Funct Biomater, 2022, 14(1): 20.
[21] Ma XR, Zhou SY, Xu XL, et al. Copper-containing nanoparticles: mechanism of antimicrobial effect and application in dentistry—a narrative review[J]. Front Surg, 2022, 9: 905892.
[22] Li RY, Li SG, Zhang Y, et al. Titanium surfaces with biomimetic topography and copper incorporation to modulate behaviors of stem cells and oral bacteria[J]. Front Bioeng Biotechnol, 2023, 11: 1223339.
[23] Baino F, Kargozar S. Regulation of the ocular cell/tissue response by implantable biomaterials and drug delivery systems[J]. Bioengineering (Basel), 2020, 7(3): 65.
[24] Cardoso GC, Barbaro K, Kuroda PAB, et al. Silver containing antimicrobial coatings on innovative Ti-30Nb-5Mo β-alloy prepared by micro-arc oxidation for biomedical implant applications[J]. Coatings, 2024, 14(2): 214.
[25] Van Hengel I, Tierolf M, Fratila-Apachitei L, et al. Antibacterial titanium implants biofunctionalized by plasma electrolytic oxidation with silver, zinc, and copper: a systematic review[J]. Int J Mol Sci, 2021, 22(7): 3800-3838.
[26] Tsutsumi Y, Niinomi M, Nakai M, et al. Electrochemical surface treatment of a β-titanium alloy to realize an antibacterial property and bioactivity[J]. Metals, 2016, 6(4): 76-84.
[27] Ding MC, Shi J, Wang WQ, et al. Early osseointegration of micro-arc oxidation coated titanium alloy implants containing Ag: a histomorphometric study[J]. BMC Oral Health, 2022, 22(1): 628-636.
[28] Shimabukuro M, Tsutsumi H, Tsutsumi Y, et al. Enhancement of antibacterial property of titanium by two-step micro arc oxidation treatment[J]. Dent Mater J, 2021, 40(3): 592-598.
[29] Reema KB, Lingaraju, Bharath Kumar T, et al. Silver nanoparticles and its medical applications[J]. REST J Emerg Trends Model Manufac, 2019, 5(4): 96-100.
[30] Yin IX, Zhang J, Zhao IS, et al. The antibacterial mechanism of silver nanoparticles and its application in dentistry[J]. Int J Nanomed, 2020, 15: 2555-2562.
[31] Salaie RN, Hassan PA, Meran ZD, et al. Antibacte-rial activity of dissolved silver fractions released from silver-coated titanium dental implant abutments: a study on Streptococcus mutans biofilm formation[J]. Antibiotics (Basel), 2023, 12(7): 1097-1107.
[32] 王月月, 黄佳慧, 孔红星, 等. 载银放射状介孔二氧化硅的制备及其在牙科树脂中的应用[J]. 无机材料学报, 2025, 40(1): 77-83.
Wang YY, Huang JH, Kong HX, et al. Silver loaded radial mesoporous silica: preparation and application in dental resins[J]. J Inorg Mater, 2025, 40(1): 77-83.
[33] Jaisankar AI, Rajeshkumar S, Ezhilarasan D. Applications of silver nanoparticles in dentistry[J]. Int J Res Pharmaceut Sci, 2020, 11(SPL3): 1126-1131.
[34] Wang QY, Zhang Y, Li Q, et al. Therapeutic applications of antimicrobial silver-based biomaterials in dentistry[J]. Int J Nanomedicine, 2022, 17: 443-462.
[35] Asensio G, Vázquez-Lasa B, Rojo L. Achievements in the topographic design of commercial titanium dental implants: towards anti-peri-implantitis surfa-ces[J]. J Clin Med, 2019, 8(11): 1982-2009.
[36] Haugen H, Makhtari S, Ahmadi S, et al. The antibacterial and cytotoxic effects of silver nanoparticles coated titanium implants: a narrative review[J]. Materials (Basel), 2022, 15(14): 5025-5043.
[37] Shimabukuro M, Tsutsumi Y, Nozaki K, et al. Chemical and biological roles of zinc in a porous titanium dioxide layer formed by micro-arc oxidation[J]. Coatings, 2019, 9(11): 705-719.
[38] Zhang X, Zhou WC, Xi WH. Advancements in incorporating metal ions onto the surface of biomedical titanium and its alloys via micro-arc oxidation: a research review[J]. Front Chem, 2024, 12: 1353950.
[39] Wang Z, Wang XJ, Wang YR, et al. NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance[J]. J Nanobiotechnol, 2021, 19(1): 353-375.
[40] Quezada-Morales P, Luengo-Machuca L, Quezada-Aguiluz M, et al. Antibacterial activity of zinc oxide nanoparticles in self- curing acrylic resin against Streptococcus mutans [J]. Int J Odontostomat, 2021, 15(3): 694-701.
[41] Gunputh UF, Le HR, Besinis A, et al. Multilayered composite coatings of titanium dioxide nanotubes decorated with zinc oxide and hydroxyapatite nanoparticles: controlled release of Zn and antimicrobial properties against Staphylococcus aureus [J]. Int J Nanomed, 2019, 14: 3583-3600.
[42] Oh SH, Jung YS, Lee MJ. Assessment of zinc-bound phosphate-based glass-coated denture-reli-ning material with antifungal efficacy for inhibiting denture stomatitis[J]. Nanomaterials (Basel), 2022, 12(17): 3048-3058.
[43] Tsutsumi H, Tsutsumi Y, Shimabukuro M, et al. Investigation of the long-term antibacterial properties of titanium by two-step micro-arc oxidation treatment[J]. Coatings, 2021, 11(7): 798.
[44] Wu F, Xu RG, Yu XL, et al. Enhanced biocompatibility and antibacterial activity of selective laser melting titanium with zinc-doped micro-nano topo-graphy[J]. J Nanomater, 2019, 2019: 5432040.
[45] Caruso S, Valenti C, Marinucci L, et al. Systematic review of zinc's benefits and biological effects on oral health[J]. Materials (Basel), 2024, 17(4): 800-824.
[46] Lee MJ, Seo YB, Seo JY, et al. Development of a bioactive flowable resin composite containing a zinc-doped phosphate-based glass[J]. Nanomaterials (Basel), 2020, 10(11): 2311-2322.
[47] Alshammari H, Bakitian F, Neilands J, et al. Antimicrobial properties of strontium functionalized tita-nium surfaces for oral applications, a systematic review[J]. Coatings, 2021, 11(7): 810-823.
[48] Ullah I. 含锶锌羟基磷灰石及其等离子喷涂层的合成与表征[D]. 合肥: 中国科学技术大学, 2020.
Ullah I. Synthesis and characterization of strontium and zinc binary substituted hydroxyapatite and its plasma spray coating for orthopaedic applications[D]. Hefei: University of Science and Technology of China, 2020.
[49] Kheirmand-Parizi M, Doll-Nikutta K, Gaikwad A, et al. Effectiveness of strontium/silver-based tita-nium surface coatings in improving antibacterial and osteogenic implant characteristics: a systematic review of in-vitro studies[J]. Front Bioeng Biotechnol, 2024, 12: 1346426.
[50] Jennes ME, Naumann M, Peroz S, et al. Antibacte-rial effects of modified implant abutment surfaces for the prevention of peri-implantitis—a systematic review[J]. Antibiotics (Basel), 2021, 10(11): 1350.
[51] Awais M, Aizaz A, Nazneen A, et al. A review on the recent advancements on therapeutic effects of ions in the physiological environments[J]. Prosthesis, 2022, 4(2): 263-316.
[52] Ciobanu G, Harja M. Bismuth-doped nanohydroxyapatite coatings on titanium implants for improved radiopacity and antimicrobial activity[J]. Nanomaterials (Basel), 2019, 9(12): 1696-1705.
[53] Cochis A, Azzimonti B, Chiesa R, et al. Metallurgical gallium additions to titanium alloys demonstrate a strong time-increasing antibacterial activity without any cellular toxicity[J]. ACS Biomater Sci Eng, 2019, 5(6): 2815-2820.
[54] Li FP, Huang K, Wang JB, et al. A dual functional Ti-Ga alloy: inhibiting biofilm formation and osteoclastogenesis differentiation via disturbing iron metabolism[J]. Biomater Res, 2023, 27(1): 24.
[55] McHendrie R, Xiao WL, Truong VK, et al. Gallium-containing materials and their potential within new-generation titanium alloys for biomedical applications[J]. Biomimetics (Basel), 2023, 8(8): 573-597.
[56] Jiao JY, Zhang ST, Qu XH, et al. Recent advances in research on antibacterial metals and alloys as implant materials[J]. Front Cell Infect Microbiol, 2021, 11: 693939.
[57] Cardoso GC, Barbaro K, Kuroda PAB, et al. Incorporation of Ca, P, Mg, and Zn elements in Ti-30Nb-5Mo alloy by micro-arc oxidation for biomedical implant applications: surface characterization, cellular growth, and microorganisms' activity[J]. Coa-tings, 2023, 13(9): 1577-1595.
[58] Feng ZQ, Li CX, Xin C, et al. Composite microarc oxidation coatings containing Cu on titanium alloy[J]. RSC Adv, 2024, 14(44): 32602-32612.
[59] Zhou WC, Huang O, Gan YZ, et al. Effect of tita-nium implants with coatings of different pore sizes on adhesion and osteogenic differentiation of BMSCs[J]. Artif Cells Nanomed Biotechnol, 2019, 47(1): 290-299.
[60] Santiago-Medina P, Sundaram PA, Diffoot-Carlo N. The effects of micro arc oxidation of gamma tita-nium aluminide surfaces on osteoblast adhesion and differentiation[J]. J Mater Sci Mater Med, 2014, 25(6): 1577-1587.
[61] Yang Y, Lin YJ, Xu RG, et al. Micro/nanostructured topography on titanium orchestrates dendritic cell adhesion and activation via β2 integrin-FAK signals[J]. Int J Nanomed, 2022, 17: 5117-5136.
[62] Zhao QM, Wu JS, Zhang SJ, et al. Preparation and properties of composite manganese/fluorine coatings on metallic titanium[J]. RSC Adv, 2023, 13(22): 14863-14877.
[63] Kuvyrkou YU, Brezhneva N, Skorb EV, et al. The influence of the morphology of titania and hydroxyapatite on the proliferation and osteogenic differen-tiation of human mesenchymal stem cells[J]. RSC Adv, 2021, 11(7): 3843-3853.
[64] 鞠昊, 宋雨来, 李志民, 等. 一步微弧氧化法处理钛合金的体外生物相容性研究[J]. 中国实用口腔科杂志, 2018, 11(6): 358-360.
Ju H, Song YL, Li ZM, et al. In vitro biological response of titanium alloy treated by one-step micro-arc oxidation[J]. Chin J Pract Stomatol, 2018, 11(6): 358-360.
[65] Kim J, Lee H, Jang TS, et al. Characterization of titanium surface modification strategies for osseointegration enhancement[J]. Metals, 2021, 11(4): 618.
[66] Wang R, Ni SL, Ma L, et al. Porous construction and surface modification of titanium-based mate-rials for osteogenesis: a review[J]. Front Bioeng Biotechnol, 2022, 10: 973297.
[67] 唐伟清, 罗军明, 陈宇海, 等. TC4钛合金表面激光冲击强化-微弧氧化涂层的组织和性能[J]. 材料热处理学报, 2023, 44(3): 144-151.
Tang WQ, Luo JM, Chen YH, et al. Microstructure and properties of laser shock strengthened micro arc oxidation coating on TC4 titanium alloy surface[J]. Trans Mater Heat Treat, 2023, 44(3): 144-151.
[68] Almashhadani HA, Abed Saleh K. Electrochemical deposition of hydroxyapatite co-substituted by Sr/Mg Coating on Ti-6Al-4V ELI dental alloy post-MAO as anti-corrosion[J]. Iraqi J Sci, 2020, 61(11): 2751-2761.
[69] Makurat-Kasprolewicz B, Wekwejt M, Ronowska A, et al. Influence of ultrasound on the characteristics of CaP coatings generated via the micro-arc oxidation process in relation to biomedical engineering[J]. ACS Biomater Sci Eng, 2024, 10(4): 2100-2115.
[70] Zhao QM, Wu JS, Li YK, et al. Promotion of bone formation and antibacterial properties of titanium coated with porous Si/Ag-doped titanium dioxide[J]. Front Bioeng Biotechnol, 2022, 10: 1001514.
[71] Kang BB, Lan D, Liu L, et al. Antibacterial activity and bioactivity of Zn-doped TiO2 coating for implants[J]. Coatings, 2022, 12(9): 1264.
[72] Tsutsumi Y, Tsutsumi H, Manaka T, et al. Development of a surface treatment to achieve long-lasting antimicrobial properties and non-cytotoxicity throu-gh simultaneous incorporation of Ag and Zn via two-step micro-arc oxidation[J]. Coatings, 2023, 13(3): 627.
[73] Sun X, Yang SD, Tong S, et al. Study on exosomes promoting the osteogenic differentiation of ADSCs in graphene porous titanium alloy scaffolds[J]. Front Bioeng Biotechnol, 2022, 10: 905511.
[74] Sheng X, Wang A, Wang ZH, et al. Advanced surface modification for 3D-printed titanium alloy implant interface functionalization[J]. Front Bioeng Biotechnol, 2022, 10: 850110.
[75] Pluhator MM, Thomson AB, Fedorak RN. Clinical aspects of trace elements: zinc in human nutrition-zinc metabolism[J]. Can J Gastroenterol Hepatol, 1995, 9(6): 327-332.
[76] 胡阳. Ti-6Al-4V表面微弧氧化电沉积工艺以及相关性能的研究[D]. 长春: 吉林大学, 2022.
Hu Y. Investigation of Ti-6Al-4V surface microarc oxidation electrodeposition process and related pro-perties[D]. Changchun: Jilin University, 2022.
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