Int J Stomatol

Int J Stomatol ›› 2025, Vol. 52 ›› Issue (1): 61-68.doi: 10.7518/gjkq.2025011

• Original Articles • Previous Articles     Next Articles

Effects of cannabinoid type Ⅰ receptor inhibition and activation on hard-palate mucosal wound healing in rats

Hailun Long1,2(),Xu Su2,Wufanbieke Baheti2,Yong Zhang3,Xiaotao Chen1,2()   

  1. 1.Dept. of Stomatology, School of Medicine, Shihezi University, Shihezi 832003, China
    2.Dept. of Stomatology, People ’ s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
    3.School of Stomatology, Peking University, Beijing 100081, China
  • Received:2024-01-22 Revised:2024-05-23 Online:2025-01-01 Published:2025-01-11
  • Contact: Xiaotao Chen E-mail:kezekq10@163.com;1440945785@qq.com
  • Supported by:
    National Natural Science Foundation of China(82260195)

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Abstract:

Objective This study aimed to explore the risk factors and prevention strategies of secondary caries in children. Methods A total of 120 children with dental caries who were re-examined 1 year after treatment in the First Affilia-ted Hospital of Zhengzhou University were divided into the secondary group (n=25) and non-secondary group (n=95). The general data, initial diagnosis data, and oral behavior data of the two groups were collected and compared. The risk factors of secondary caries in children with dental caries were analyzed by using logistic regression. Results Significant differences in age, parental education level, family income, filling materials, brushing frequency, parental help to brush teeth, mouthwash after meals, sweets intake times, regular oral review, and use of fluoride toothpaste were found between the secondary caries group and non-secondary caries group (P<0.05). Multivariate Logistic regression analysis showed that the educational level of parents, parental help to brush teeth, mouthwash after meals, brushing frequency, sweets intake times, use of fluoride toothpaste, and filling materials were independent risk factors for secondary caries in children (P<0.05). Conclusion Secondary caries in children have many risk factors. Thus, reducing secondary caries in children is important to strengthen oral health education and develop good oral health habits.

Key words: wound healing, cannabinoid type Ⅰ receptor, hard-palate mucosa

CLC Number: 

  • Q257

TrendMD: 

Fig 1

Schematic representation of rat palatal mucosal trauma and schematic representation of tissue samples"

Fig 2

Observation of plane wound closure during wound healing"

Fig 3

Representative pictures of 3 groups of rats on 3 and 7 days HE staining × 200"

Fig 4

Representative CB1R picture of rat gingival trauma immunohistochemical staining × 200"

Fig 5

CB1R expression in the three groups of rats"

Fig 6

Expression of CB1R protein within 7 days in the three groups of rats"

Fig 7

CB1R protein expression levels in the three groups of rats"

Fig 8

Cytokine content was measured in gingival wound tissue homogenates from group Model (left), R-H(middle) and AEA (right)"

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