Smads, bone morphogenetic proteins, signal transduction,"/> The role of Smads and r elated tr anscr iption factor s in the signal tr ansduction of bone morphogenetic protein
Int J Stomatol

Inter J Stomatol ›› 2008, Vol. 35 ›› Issue (2): 135-137.

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The role of Smads and r elated tr anscr iption factor s in the signal tr ansduction of bone morphogenetic protein

YANG Liu- qing, LIN Zheng- mei   

  1. Dept. of Endodontics, Hospital of Stomatology, Guanghua College of Stomatology, Sun Yat- Sen University, Guangzhou 510055, China
  • Received:2007-08-06 Revised:2007-12-08 Online:2008-03-20 Published:2008-03-20
  • Contact: LIN Zheng- mei

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Abstract:

Bone morphogenetic proteins（BMPs） have been shown to be multifunctional cytokines with a wide range of biological activities on various cell types. Smads proteins transduce BMPs intercellular signals into the nucleus and regulate transcription of target genes. In the nucleus, various Smad- binding proteins interact with the transcription complex, which may play critical roles in regulating the transcription of BMPs- related genes. In this review, we emphasis on the BMPs- Smad pathway and Smad binding proteins including transcription factors, transcriptional co- activators and co- repressors.

Key words: Smads')">Smads, bone morphogenetic proteins, signal transduction


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