Int J Stomatol

Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (2): 218-220.doi: 10.3969/j.issn.1673-5749.2011.02.025

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Effect and regulatory mechanisms of mechanical strain on the expression of core binding factor-α1

GUO Ping1, LIN Xin-ping2.   

  1. 1. Dept. of Orthodontics, The Affiliated Stomatological Hospital of Medical College, Zhejiang University, Hangzhou 310006, China; 2. Dept. of Orthodontics, The Affiliated Stomatological Hospital of Medical College, Zhejiang Chinese Medical University, Hangzhou 310006, China
  • Received:2010-03-12 Revised:2010-08-20 Online:2011-03-20 Published:2011-03-20

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Abstract:

Core binding factor（Cbf）-α1 is an important transcription factor which is necessary for bone modeling and bone remodeling. Mechanical stress is regarded as a key factor for the regulation of bone remodeling. This article was to review the structure of the Cbf-α1, the relationship between Cbf-α1 and bone remodeling, recent research progress in regulation of mechanical forces on the Cbf-α1 expression.

Key words: core binding factor-&alpha, 1； bone remodeling； mechanical stress； signal pathway； mitogen-activated protein kinase


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