Abstract: Quorum sensing is a process of cell-to-cell communication in Streptococcus mutans which secretes a special signal molecule-competence stimulating peptide（CSP）, then to induce and to activate the expression of related genes. Mutacin is antimicrobial substance produced by Streptococcus mutans, which coordinates biological behavior of related bacteria. However, quorum sensing can regulate mutacin to communicate with oral bacteria and regulate the stability of biofilm. This review summarized the reserch progress of mutacins regulated by quorum sensing in Streptococcus mutans in recent years.