Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (1): 101-104.doi: 10.3969/j.issn.1673-5749.2012.01.028

Previous Articles     Next Articles

Research advances on inhibition receptor activator of nuclear factor-κB and its ligand in periodontal treatment

Chen Bin, Sun Weibin.   

  1. Dept. of Periodontics, The Affiliated Stomatological Hospital of Medical College, Nanjing University, Nanjing 210008, China
  • Received:2010-08-16 Revised:2011-08-04 Online:2012-01-01 Published:2012-01-01

RichHTML

3

PDF (PC)

702

Abstract:

Receptor activator of nuclear factor-κB（RANK）/receptor activator of nuclear factor-κB ligand（RANKL） play a critical role in alveolar bone resorption though affecting osteoclasts formation and activation, therefore, we can inhibit periodontal bone resorption though RANKL/RANK inhibition. Osteoprotegerin（OPG） protects bone from excessive resorption by binding to RANKL and preventing it from binding to RANK. In this paper, we will review the relationship between RANKL/RANK/OPG signaling pathway and periodontal disease, and we will mainly focus on the possibility of periodontal treatment with RANKL/RANK inhibition.

Key words: receptor activator of nuclear factor-&kappa, B/receptor activator of nuclear factor-&kappa, B ligand pathway； periodontal treatment； periodontal bone resorption


TrendMD: 
[1] Tang Kunqi, Yan Fuhua.. Application of osteoprotegerin in periodontal tissue regeneration [J]. Inter J Stomatol, 2011, 38(5): 546-549.
[2] CHEN Shen-yuan, CHAO Yong-lie.. Research progress on molecular regulation of bone metabolism [J]. Inter J Stomatol, 2010, 37(5): 544-547.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .