Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (4): 437-439,443.doi: 10.3969/j.issn.1673-5749.2010.04.017

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Interaction of core binding factor-α1 and parathyroid hormone related protein in chondrogenesis

CHENG Gu1, LI Zu-bing2.   

  1. （1. The State Key Laboratory Breeding Base of Basic Science of Stomatology（Hubei-MOST） & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan 430079,
  • Online:2010-07-20 Published:2010-07-20

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Abstract: Chondrocytes will differentiate and become hypertrophy in endochondral ossification. In this process, core binding factor α1（cbf-α1）, promotes the hypertrophy of the chondrocytes. But parathyroid hormone related protein （PTHrP） can delays this process through Cbf-α1-dependent and independent pathways. The following are my summarizes, on which we clearly stated about the affects of Cbf-α1 to chondrocytes and PTHrP to endochondral ossification. We also showed that how PTHrP delays the hypertrophy of the chondrocytes and how PTHrP inhibits the impression of cbf-α1.

Key words: endochondral ossification, core binding factor-α1, parathyroid hormone related protein


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