Abstract:

Objective This study aims to establish the obstructive sleep apnea syndrome(OSAS) animal model in rats with periodontitis and to explore the correlation between OSAS and periodontitis. Methods Twenty SD rats were randomly divided into the control group(group A) and intermitted hypoxia exposure group(group B). The oxygen concentration in the cabin ranged from 10%±0.5% to 21%±0.5% through the circular input of oxygen and nitrogen for 8 h daily. Each SD rat received wire ligatures around the cervix of the left second maxillary molar, whereas the contralateral tooth was untreated as control. The rats were sacrificed after right weeks. X-ray and histological examination were used to evaluate the periodontal breakdown. Results The periodontal depth, sulcular bleeding index, and alveolar bone loss of the ligatured teeth significantly increased, especially in group B. Conclusion Intermittent hypoxia can aggravate periodontal inflammation and may also be a risk factor for periodontics.