牙槽骨角形吸收的危险因素研究进展

doi:10.7518/gjkq.2026608

摘要/Abstract

摘要：

牙槽骨角形吸收又称为垂直型牙槽骨吸收，常常形成骨下袋。在缺乏牙周系统治疗干预的情况下，角形吸收部位进一步丧失牙槽骨的风险增加，因此早期预判和及时治疗十分重要，而这需要明确牙槽骨角形吸收发生的可能危险因素。本研究对牙槽骨角形吸收发生的微生物学因素、局部促进因素、生物学因素、行为因素、全身因素和医源性因素进行论述。

关键词: 牙周炎, 牙槽骨吸收, 角形吸收, 危险因素

Abstract:

Alveolar bone angular resorption, also known as vertical alveolar bone resorption, often forms infra-bony pockets. In the absence of periodontal system treatment, these sites are at increased risk of further alveolar bone loss. Thus, early prediction and timely treatment are important; nevertheless, this requires the identification of various risk factors for alveolar bone angular resorption. This article reviews the microbiological, biological, behavioral, local, systemic, and iatrogenic risk factors associated with angular resorption of alveolar bone.

Key words: periodontitis, alveolar bone resorption, angular resorption, risk factor

中图分类号:

R781.4

刘熠,潘亚萍. 牙槽骨角形吸收的危险因素研究进展[J]. 国际口腔医学杂志, 2026, 53(3): 362-369.

Yi Liu,Yaping Pan. Analysis and research progress on risk factors for alveolar bone angular resorption[J]. Int J Stomatol, 2026, 53(3): 362-369.

参考文献 60

[1]	Zhang MZ, Liu YL, Afzali H, et al. An update on periodontal inflammation and bone loss[J]. Front Immunol, 2024, 15: 1385436.
[2]	Papapanou PN, Wennström JL. The angular bony defect as indicator of further alveolar bone loss[J]. J Clin Periodontol, 1991, 18(5): 317-322.
[3]	van der Weijden GA, Timmerman MF, Reijerse E, et al. The prevalence of A. actinomycetemcomitans, P. gingivalis and P. intermedia in selected subjects with periodontitis[J]. J Clin Periodontol, 1994, 21(9): 583-588.
[4]	Jansson L, Ehnevid H, Lindskog S, et al. Relationship between periapical and periodontal status. A clinical retrospective study[J]. J Clin Periodontol, 1993, 20(2): 117-123.
[5]	Kim T, Miyamoto T, Nunn ME, et al. Root proximity as a risk factor for progression of alveolar bone loss: the Veterans Affairs Dental Longitudinal Study[J]. J Periodontol, 2008, 79(4): 654-659.
[6]	Waerhaug J. The infrabony pocket and its relationship to trauma from occlusion and subgingival plaque[J]. J Periodontol, 1979, 50(7): 355-365.
[7]	Rams TE, Listgarten MA, Slots J. Radiographic alveolar bone morphology and progressive periodontitis[J]. J Periodontol, 2018, 89(4): 424-430.
[8]	Müller HP, Ulbrich M. Alveolar bone levels in adults as assessed on panoramic radiographs. (Ⅰ) Prevalence, extent, and severity of even and angular bone loss[J]. Clin Oral Investig, 2005, 9(2): 98-104.
[9]	Baljoon M, Natto S, Bergstrom J. Occurrence of vertical bone defects in dentally aware individuals[J]. Acta Odontol Scand, 2003, 61(1): 47-51.
[10]	Kasaj A, Vasiliu C, Willershausen B. Assessment of alveolar bone loss and angular bony defects on pa-noramic radiographs[J]. Eur J Med Res, 2008, 13(1): 26-30.
[11]	Papapanou PN, Tonetti MS. Diagnosis and epidemiology of periodontal osseous lesions[J]. Periodontol 2000, 2000, 22(1): 8-21.
[12]	Enberg N, Wolf J, Ainamo A, et al. Dental diseases and loss of teeth in a group of Finnish alcoholics: a radiological study[J]. Acta Odontol Scand, 2001, 59(6): 341-347.
[13]	Nibali L, Sultan D, Arena C, et al. Periodontal infrabony defects: systematic review of healing by defect morphology following regenerative surgery[J]. J Clin Periodontol, 2021, 48(1): 100-113.
[14]	Baljoon M. Tobacco smoking and vertical periodontal bone loss[J]. Swed Dent J Suppl, 2005(174): 1-62.
[15]	Passanezi E, Sant’Ana ACP. Role of occlusion in periodontal disease[J]. Periodontol 2000, 2019, 79(1): 129-150.
[16]	Kato T, Fujiwara N, Kuraji R, et al. Relationship between periodontal parameters and non-vital pulp in dental clinic patients: a cross-sectional study[J]. BMC Oral Heal, 2020, 20: 109.
[17]	Koidou VP, Hagi-Pavli E, Cross S, et al. Molecular profiling of intrabony defects’ gingival crevicular fluid[J]. J Periodontal Res, 2022, 57(1): 152-161.
[18]	Cheng XQ, Zhou XD, Liu CC, et al. Oral osteomicrobiology: the role of oral microbiota in alveolar bone homeostasis[J]. Front Cell Infect Microbiol, 2021, 11: 751503.
[19]	Evans RT, Klausen B, Ramamurthy NS, et al. Perio-dontopathic potential of two strains of Porphyromonas gingivalis in gnotobiotic rats[J]. Arch Oral Biol, 1992, 37(10): 813-819.
[20]	Hbibi A, Bouziane A, Lyoussi B, et al. Aggregatibacter actinomycetemcomitans: from basic to advan-ced research[M]//Advances in experimental medicine and biology. Cham: Springer International Publishing, 2022: 45-67.
[21]	Herbert BA, Novince CM, Kirkwood KL. Aggrega-tibacter actinomycetemcomitans, a potent immunoregulator of the periodontal host defense system and alveolar bone homeostasis[J]. Mol Oral Microbiol, 2016, 31(3): 207-227.
[22]	Yu B, Wang CY. Osteoporosis and periodontal di-seases—an update on their association and mechanistic links[J]. Periodontol 2000, 2022, 89(1): 99-113.
[23]	季娟娟, 姚霜, 刘晓君, 等. 成人不同错𬌗畸形分类与垂直型牙槽骨吸收的关系研究[J]. 牙体牙髓牙周病学杂志, 2014, 24(10): 599-601.
	Ji JJ, Yao S, Liu XJ, et al. Relation between ma-locclusion type and vertical alveolar resorption[J]. Chin J Conserv Dent, 2014, 24(10): 599-601.
[24]	赵馨瑗, 张晓蓉. 安氏Ⅱ类2分类错𬌗畸形上前牙区牙及牙槽骨形态特征研究[J]. 中国美容医学, 2023, 32(9): 197-201.
	Zhao XY, Zhang XR. Morphological characteristics of upper anterior teeth and alveolar bone in adult angle Class Ⅱ Division 2 malocclusion[J]. Chin J Aesthet Med, 2023, 32(9): 197-201.
[25]	Wang MJ, Jun J, Xin Z, et al. GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway[J]. J Cell Mol Med, 2024, 28(7): e18231.
[26]	Kramer GM. A consideration of root proximity[J]. Int J Periodontics Restorative Dent, 1987, 7(6): 8-33.
[27]	Artun J, Kokich VG, Osterberg SK. Long-term effect of root proximity on periodontal health after orthodontic treatment[J]. Am J Orthod Dentofacial Orthop, 1987, 91(2): 125-130.
[28]	Aykol-Sahin G, Arsan B. Furcation area and root proximity of molars as a risk indicator of periodontitis: a cone‑beam computed tomography-based study[J]. Oral Radiol, 2023, 39(4): 802-810.
[29]	Aykol-Sahin G, Arsan B, Altan-Koran SM, et al. Association between root taper and root proximity of single-rooted teeth with periodontitis: a cone-beam computed tomography based study[J]. Odontology, 2022, 110(2): 356-364.
[30]	Jansson L. Relationship between apical periodontitis and marginal bone loss at individual level from a general population[J]. Int Dent J, 2015, 65(2): 71-76.
[31]	Yu MY, Li JN, Liu S, et al. Diagnosis of cracked tooth: clinical status and research progress[J]. Jpn Dent Sci Rev, 2022, 58: 357-364.
[32]	See WK, Ho JC, Huang CF, et al. The association between clinical diagnostic factors and the prevalence of vertical root fracture in endodontic surgery[J]. J Formos Med Assoc, 2019, 118(3): 713-720.
[33]	Huang RJ, Zhou CC, Zhan L, et al. Experts consensus on management of tooth luxation and avulsion[J]. Int J Oral Sci, 2024, 16(1): 57.
[34]	周佳佳, 赵蕾, 徐欣. 牙周炎相关基因多态性的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 432-440.
	Zhou JJ, Zhao L, Xu X. Research progress on the genetic polymorphism of periodontitis[J]. Int J Stomatol, 2022, 49(4): 432-440.
[35]	Mazurek-Mochol M, Bonsmann T, Mochol M, et al. The role of interleukin 6 in periodontitis and its complications[J]. Int J Mol Sci, 2024, 25(4): 2146.
[36]	DiRienzo JM, Slots J. Genetic approach to the study of epidemiology and pathogenesis of Actinobacillus actinomycetemcomitans in localized juvenile perio-dontitis[J]. Arch Oral Biol, 1990, 35: S79-S84.
[37]	Xu JY, Yu L, Ye SR, et al. Oral microbiota-host interaction: the chief culprit of alveolar bone resorption[J]. Front Immunol, 2024, 15: 1254516.
[38]	陈梦洁, 徐文华, 刘青青, 等. 全身免疫炎症指数与牙周炎患者分级诊断的相关性研究[J]. 国际口腔医学杂志, 2024, 51(6): 706-712.
	Chen MJ, Xu WH, Liu QQ, et al. Correlation analysis between the systemic immune-inflammatory index and graded diagnosis in patients with perio-dontitis[J]. Int J Stomatol, 2024, 51(6): 706-712.
[39]	Li Y, Ling JQ, Jiang QZ. Inflammasomes in alveolar bone loss[J]. Front Immunol, 2021, 12: 691013.
[40]	吴丹丹, 刘琪. 表观遗传学对牙周疾病及牙周细胞成骨和骨再生的作用机制[J]. 中国组织工程研究, 2021, 25(35): 5716-5722.
	Wu DD, Liu Q. Epigenetic mechanisms in periodontal disease, periodontal cell osteogenesis and bone regeneration[J]. Chin J Tiss Eng Res, 2021, 25(35): 5716-5722.
[41]	Amaranath BJ, Das N, Gupta I, et al. Types of bone destruction and its severity in chronic periodontitis patients with tobacco smoking habit using periapical radiographs and transgingival probing: a cross-sectional study[J]. J Indian Soc Periodontol, 2020, 24(1): 20-25.
[42]	Malhotra R, Kapoor A, Grover V, et al. Nicotine and periodontal tissues[J]. J Indian Soc Periodontol, 2010, 14(1): 72-79.
[43]	Gandhi UH, Benjamin A, Gajjar S, et al. Alcohol and periodontal disease: a narrative review[J]. Cu-reus, 2024, 16(6): e62270.
[44]	Tagger-Green N, Refael A, Szmukler-Moncler S, et al. The association of systemic condition and medications on alveolar bone loss and tooth attrition[J]. Quintessence Int, 2024, 55(8): 616-628.
[45]	Zhu L, Zhou C, Chen S, et al. Osteoporosis and alveolar bone health in periodontitis niche: a predisposing factors-centered review[J]. Cells, 2022, 11(21): 3380.
[46]	Munhoz L, Takahashi DY, Nishimura DA, et al. Do patients with osteoporosis have higher risk to pre-sent reduced alveolar ridge height? An imaging ana-lysis[J]. Indian J Dent Res, 2019, 30(5): 747-750.
[47]	Zhao PF, Xu AM, Leung WK. Obesity, bone loss, and periodontitis: the interlink[J]. Biomolecules, 2022, 12(7): 865.
[48]	Moon JS, Lee SY, Kim JH, et al. Synergistic alveolar bone resorption by diabetic advanced glycation end products and mechanical forces[J]. J Periodontol, 2019, 90(12): 1457-1469.
[49]	Al Bayaty FH, Mahmod SA, Jamil Al-Obaidi MM, et al. Effect of osteoarthritis on alveolar bone loss in experimental periodontitis in rats[J]. J Periodontal Res, 2023, 58(1): 22-28.
[50]	Jepsen K, Sculean A, Jepsen S. Complications and treatment errors involving periodontal tissues rela-ted to orthodontic therapy[J]. Periodontol 2000, 2023, 92(1): 135-158.
[51]	Wennström JL, Stokland BL, Nyman S, et al. Perio-dontal tissue response to orthodontic movement of teeth with infrabony pockets[J]. Am J Orthod Dentofac Orthop, 1993, 103(4): 313-319.
[52]	Thilander B. Infrabony pockets and reduced alveolar bone height in relation to orthodontic therapy[J]. Semin Orthod, 1996, 2(1): 55-61.
[53]	Morais JF, Melsen B, de Freitas KMS, et al. Evaluation of maxillary buccal alveolar bone before and after orthodontic alignment without extractions: a cone beam computed tomographic study[J]. Angle Orthod, 2018, 88(6): 748-756.
[54]	Carvalho BAS, Duarte CAB, Silva JF, et al. Clinical and radiographic evaluation of the periodontium with biologic width invasion[J]. BMC Oral Heal, 2020, 20: 116.
[55]	Ozan O, Orhan K, Aksoy S, et al. The effect of removable partial dentures on alveolar bone resorption: a retrospective study with cone-beam compu-ted tomography[J]. J Prosthodont, 2013, 22(1): 42-48.
[56]	Katsamakis S, Timmerman M, van der Velden U, et al. Patterns of bone loss around teeth restored with endodontic posts[J]. J Clin Periodontol, 2009, 36(11): 940-949.
[57]	Peng X, Cheng L, You Y, et al. Oral microbiota in human systematic diseases[J]. Int J Oral Sci, 2022, 14: 14.
[58]	Graves DT, Corrêa JD, Silva TA. The oral microbiota is modified by systemic diseases[J]. J Dent Res, 2019, 98(2): 148-156.
[59]	Flueraşu MI, Bocşan IC, Țig IA, et al. The epidemiology of bruxism in relation to psychological factors[J]. Int J Environ Res Public Heal, 2022, 19(2): 691.
[60]	Boscato N, Nascimento GG, Leite FRM, et al. Role of occlusal factors on probable bruxism and orofacial pain: data from the 1982 Pelotas birth cohort study[J]. J Dent, 2021, 113: 103788.

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