国际口腔医学杂志

国际口腔医学杂志 ›› 2025, Vol. 52 ›› Issue (5): 684-690.doi: 10.7518/gjkq.2025080

• 综述 • 上一篇    下一篇

牙槽窝敷料的应用及研究进展

胡海琨1(),郭雨璇2,胡洪滔2,王了3()   

  1. 1.口腔疾病防治全国重点实验室;国家口腔医学中心 国家口腔疾病临床医学研究中心;四川大学华西口腔医院锦江门诊部 成都 610066
    2.口腔疾病防治全国重点实验室;国家口腔医学中心 国家口腔疾病临床医学研究中心;四川大学华西口腔医学院 成都 610041
    3.口腔疾病防治全国重点实验室;国家口腔医学中心 国家口腔疾病临床医学研究中心;四川大学华西口腔医院口腔颌面外科 成都 610041
  • 收稿日期:2024-08-28 修回日期:2025-01-09 出版日期:2025-09-01 发布日期:2025-08-27
  • 通讯作者: 王了
  • 作者简介:胡海琨，主治医师，博士，Email：Helen-8591@163.com
  • 基金资助:
    四川大学华西口腔医院探索与研发项目(LCYJ-2023-DL-3)

Application and research progress of alveolar socket dressings

Haikun Hu1(),Yuxuan Guo2,Hongtao Hu2,Liao Wang3()   

  1. 1.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Jinjiang Clinic, West China Hospital of Stomatology, Sichuan University, Chengdu 610066, China
    2.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases＆ West China School of Stomatology, Sichuan University, Chengdu 610041, China
    3.State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2024-08-28 Revised:2025-01-09 Online:2025-09-01 Published:2025-08-27
  • Contact: Liao Wang
  • Supported by:
    Research and Develop Program West China Hospital of Stomatology Sichuan University(LCYJ-2023-DL-3)

RichHTML

2

PDF (PC)

10

摘要：

传统牙槽窝敷料以填塞类材料为主，虽然具备基本的止血和创口保护功能，但在机械强度、生物学性能，特别是促进牙槽窝组织再生等方面存在局限。随着生物材料科学的发展，兼具创面保护和促进愈合的新型牙槽窝敷料逐渐成为研究和临床应用的热点，这些敷料不仅能够保护创面，还能促进愈合，适用于复杂的口腔环境。其中，具有止血、抗炎、抗菌和药物递送功能的复合型水凝胶作为牙槽窝敷料，能够显著改善术后的愈合效果，为牙拔除术后管理提供了更为有效的方案。

关键词: 牙槽窝敷料, 生物材料, 牙槽窝愈合

Abstract:

Traditional dressings primarily involve packing materials that provide basic hemostatic and wound-protective functions. However, they exhibit limitations in terms of mechanical strength and biological properties and particularly in promoting tissue regeneration within the alveolar socket. With the advancement of biomaterials science, innovative alveolar socket dressings that combine wound protection with enhanced healing capabilities have increasingly become a focal point in research and clinical practice. These advancements promise to deliver optimal post-operative management solutions for alveolar sockets in complex oral environments. Notably, composite hydrogels with integrated hemostatic, anti-inflammatory, antibacterial, and drug-delivery functions are emerging as promising materials for alveolar socket dres-sings, potentially offering improved management strategies for post-extraction care and enhancing the healing outcomes of the alveolar socket.

Key words: alveolar socket dressings, biomaterials, alveolar socket healing

中图分类号: 

  • R782.05

《口腔诊疗必备数字化技术全流程详解》出版发行"

[1] Araújo MG, Silva CO, Misawa M, et al. Alveolar socket healing: what can we learn[J]. Periodontol 2000, 2015, 68(1): 122-134.
[2] Discepoli N, Vignoletti F, Laino L, et al. Early hea-ling of the alveolar process after tooth extraction: an experimental study in the beagle dog[J]. J Clin Pe-riodontol, 2013, 40(6): 638-644.
[3] 严嵚, 周月鹏, 杨细虎, 等. 智齿拔牙创不同填塞处理愈合效果比较[J]. 江苏大学学报(医学版), 2017, 27(5): 442-444.
Yan Q, Zhou YP, Yang XH, et al. Comparison of healing effects of different filling treatments for wisdom tooth extraction[J]. J Jiangsu Univ (Med Ed), 2017, 27(4): 442-444.
[4] 李庆隆, 高峻鹰, 郭建茹, 等. 止血纱布和碘仿纱条用于服用阿司匹林患者拔牙后的临床研究[J]. 中国煤炭工业医学杂志, 2015, 18(7): 1161-1163.
Li QL, Gao JY, Guo JR, et al. Clinical study on the use of hemostatic gauze and iodoform gauze strips after tooth extraction in patients taking aspirin[J]. Chin J Coal Ind Med, 2015, 18(7): 1161-1163.
[5] 赵子慕, 姜瑶, 吴雨, 等. 拔牙止血方法研究现况综述[J]. 口腔医学, 2019, 39(4): 380-384.
Zhao ZM, Jiang Y, Wu Y, et al. Review of research on hemostatic methods for tooth extraction[J]. Stomatology, 2019, 39(4): 380-384.
[6] Zhu Y, Zhang L, Duan W, et al. Succinic ester-based shape memory gelatin sponge for noncompressible hemorrhage without hindering tissue regeneration[J]. Adv Healthc Mater, 2023, 12(5): e2202122.
[7] A W, Du F, He Y, et al. Graphene oxide reinforced hemostasis of gelatin sponge in noncompressible hemorrhage via synergistic effects[J]. Colloids Surf B Biointerfaces, 2022, 220: 112891.
[8] Xie X, Li D, Chen Y, et al. Conjugate electrospun 3D gelatin nanofiber sponge for rapid hemostasis[J]. Adv Healthc Mater, 2021, 10(20): e2100918.
[9] Dong Y, Liu W, Lei Y, et al. Effect of gelatin sponge with colloid silver on bone healing in infected cra-nial defects[J]. Mater Sci Eng C Mater Biol Appl, 2017, 70(Pt 1): 371-377.
[10] 郭晶晶. Gelatamp胶质银明胶海绵应用在下颌第三磨牙牙拔除术后的愈合效果观察[J]. 实用医技杂志, 2022, 29(5): 480-483.
Guo JJ. Gelatamp colloidal silver gelatin sponge application after extraction of mandibular third molar teeth observation of the healing effect[J]. J Pract Med Tech, 2022, 29(5): 480-483.
[11] 涂波. 碘仿明胶海绵预防干槽症的临床效果[J]. 临床合理用药杂志, 2022, 15(4): 110-112.
Tu B. Clinical effect of iodoform gelatin sponge in the prevention of dry socket[J]. Chin J Clin Ration Drug Use, 2022, 15(4): 110-112.
[12] Patil V, Ramaraj PN, Sharma M, et al. Effects of intraoperative placement of tetracycline, tetracycline + gelatin sponge, and placebo on postoperative pain after mandibular molar extraction: a comparative prospective study[J]. Natl J Maxillofac Surg, 2021, 12(2): 211-218.
[13] 马永清, 杨苗苗. 胶质银明胶海绵预防糖尿病患者拔牙术后并发症的临床研究[J]. 口腔医学研究, 2020, 36(12): 1168-1171.
Ma YQ, Yang MM. Effect of colloidal silver gelatin sponge on prevention of complications after tooth extraction in diabetic patients[J]. J Oral Sci Res, 2020, 36(12): 1168-1171.
[14] Wang Y, Lin J, Fu H, et al. A Janus gelatin sponge with a procoagulant nanoparticle-embedded surface for coagulopathic hemostasis[J]. ACS Appl Mater Interfaces, 2024, 16(1): 353-363.
[15] Lee CH, Singla A, Lee Y. Biomedical applications of collagen[J]. Int J Pharm, 2001, 221(1/2): 1-22.
[16] 王立臣, 陈珍, 陈江平, 等. 胶原蛋白海绵和明胶海绵预防阻生牙拔除术后并发症的比较[J]. 广东医科大学学报, 2018, 36(5): 597-599.
Wang LC, Chen Z, Chen JP, et al. Comparison of collagen sponge and gelatin sponge in preventing complications after impacted tooth extraction[J]. J Guangdong Med Univ, 2018, 36(5): 597-599.
[17] He Y, Wang JN, Si Y, et al. A novel gene recombinant collagen hemostatic sponge with excellent biocompatibility and hemostatic effect[J]. Int J Biol Macromol, 2021, 178: 296-305.
[18] Li H, Cheng WL, Liu K, et al. Reinforced collagen with oxidized microcrystalline cellulose shows improved hemostatic effects[J]. Carbohydr Polym, 2017, 165: 30-38.
[19] Yang Y, Zhang YY, Min YP, et al. Preparation of methacrylated hyaluronate/methacrylated collagen sponges with rapid shape recovery and orderly channel for fast blood absorption as hemostatic dressing[J]. Int J Biol Macromol, 2022, 222: 30-40.
[20] 许广杰, 侯锐, 杨霞, 等. 再生氧化纤维素止血纱布降低长期口服华法林患者拔牙后出血的临床研究[J]. 口腔医学, 2017, 37(9): 805-809.
Xu GJ, Hou R, Yang X, et al. Clinical analysis on the effects of oxidized regenerated cellulosein on reducing risks of postoperative hemorrhage after tooth extraction in patients taking long-term oral Warfarin[J]. Stomatology, 2017, 37(9): 805-809.
[21] Arat YO, Dorotheo EU, Tang RA, et al. Compressive optic neuropathy after use of oxidized regene-rated cellulose in orbital surgery review of complications, prophylaxis, and treatment[J]. Ophthalmology, 2006, 113(2): 333-337.
[22] Guo X, Hu H, Liu Y, et al. The effect of haemostatic agents on early healing of the extraction socket[J]. J Clin Periodontol, 2019, 46(7): 766-775.
[23] 魏中武, 黄谢山, 陈灼庚. 浓缩生长因子在口腔临床中的应用及研究进展[J]. 国际口腔医学杂志, 2020, 47(2): 235-243.
Wei ZW, Huang XS, Chen ZG. Application and research progress on concentrated growth factor in oral clinic[J]. Int J Stomatol, 2020, 47(2): 235-243.
[24] Zhang L, Yuan Z, Shafiq M, et al. An injectable integration of autologous bioactive concentrated growth factor and gelatin methacrylate hydrogel with efficient growth factor release and 3D spatial structure for accelerated wound healing[J]. Macromol Biosci, 2023, 23(4): e2200500.
[25] Scopp IW. Oral adhesive bandage[J]. J Periodontol, 1968, 39(3): 138-142.
[26] Zhou XC, Cai Y, Zhao JH. The hemostatic and comforting effects of oral adhesive bandages in tooth extraction: a randomized controlled clinical study[J]. Clin Oral Invest, 2024, 28(5): 244.
[27] Li A, Ma B, Hua S, et al. Chitosan-based injectable hydrogel with multifunction for wound healing: a critical review[J]. Carbohydr Polym, 2024, 333: 121952.
[28] Pippi R, Santoro M, Cafolla A. The use of a chitosan-derived hemostatic agent for postextraction bleeding control in patients on antiplatelet treatment[J]. J Oral Maxillofac Surg, 2017, 75(6): 1118-1123.
[29] Rajendra K, Vempalli S, Kadiyala M, et al. Effect of platelet-rich fibrin versus chitosan-based Axiostat hemostatic agent following dental extraction in cardiac patients on antiplatelet therapy: a comparative study[J]. Natl J Maxillofac Surg, 2021, 12(3): 361-366.
[30] Madrazo-Jiménez M, Rodríguez-Caballero Á, Serrera-Figallo MÁ, et al. The effects of a topical gel containing chitosan, 0.2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction[J]. Med Oral Patol Oral Cir Bucal, 2016, 21(6): e696-e702.
[31] Wei Q, Zhou J, An Y, et al. Modification, 3D prin-ting process and application of sodium alginate based hydrogels in soft tissue engineering: a review[J]. Int J Biol Macromol, 2023, 232: 123450.
[32] El Halawany M, Latif R, AbouGhaly MHH. Hemostatic alginate/nano-hydroxyapatite composite aerogel loaded with tranexamic acid for the potential protection against alveolar osteitis[J]. Pharmaceutics, 2022, 14(10): 2255.
[33] Ibraheem W, Jedaiba WH, Alnami AM, et al. Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study[J]. Eur Rev Med Pharmacol Sci, 2022, 26(10): 3444-3449.
[34] He G, Xian Y, Lin H, et al. An injectable and coagulation-independent Tetra-PEG hydrogel bioadhesive for post-extraction hemostasis and alveolar bone regeneration[J]. Bioact Mater, 2024, 37: 106-118.
[35] Li S, Zhi L, Chen Q, et al. Reversibly adhesive, anti-swelling, and antibacterial hydrogels for tooth-extraction wound healing[J]. Adv Healthc Mater, 2024, 13(14): e2400089.
[36] Wang Z, Zhang Y, Yin Y, et al. High-strength and injectable supramolecular hydrogel self-assembled by monomeric nucleoside for tooth-extraction wound healing[J]. Adv Mater, 2022, 34(13): e2108300.
[37] Guo Y, Shao Z, Wang W, et al. Periodontium-mi-micking, multifunctional biomass-based hydrogel promotes full-course socket healing[J]. Biomacromolecules, 2024, 25(2): 1246-1261.
[38] Wu J, Pan Z, Zhao ZY, et al. Anti-swelling, robust, and adhesive extracellular matrix-mimicking hydrogel used as intraoral dressing[J]. Adv Mater, 2022, 34(20): e2200115.
[1] 丁雨棠, 王剑. 口腔内伤口敷料的研究进展[J]. 国际口腔医学杂志, 2024, 51(3): 344-352.
[2] 陈克难,郭传瑸. 可降解医用镁基金属生物材料的研究进展[J]. 国际口腔医学杂志, 2021, 48(3): 322-328.
[3] 秦胜男,贾慧,李英. 聚醚醚酮在口腔临床中的应用现状[J]. 国际口腔医学杂志, 2018, 45(6): 652-656.
[4] 黄璐,钱捷. 三维有限元在嵌体修复中的研究进展[J]. 国际口腔医学杂志, 2018, 45(6): 728-733.
[5] 邱瑜蕾,包崇云. 生物材料表面细菌生物膜形成与理化特征[J]. 国际口腔医学杂志, 2008, 35(S1): -.
[6] 孙卫斌1综述 陈治清2审校. 组织工程细胞培养研究的新方法———微尺度技术[J]. 国际口腔医学杂志, 2008, 35(3): 314-314～317.
[7] 王海燕,周曾同. 表皮角化细胞培养的研究进展[J]. 国际口腔医学杂志, 2004, 31(05): 338-339.
[8] 尚政军. 全下颌骨膜下种植体的演变[J]. 国际口腔医学杂志, 2000, 27(02): -.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!