国际口腔医学杂志 ›› 2018, Vol. 45 ›› Issue (1): 78-84.doi: 10.7518/gjkq.2018.01.016

• 综述 • 上一篇    下一篇

iRoot SP的理化性质和生物学性能

彭俐, 王祖华   

  1. 北京大学口腔医学院•口腔医院牙体牙髓病科 北京 100081
  • 收稿日期:2017-03-12 修回日期:2017-08-01 发布日期:2018-01-15
  • 通讯作者: 王祖华,副主任医师,博士,Email:wangzuhua@pkuss.bjmu.edu.cn
  • 作者简介:彭俐,学士,Email:pengli_211@163.com
  • 基金资助:

The current state of physicochemical properties and biological performance researches on iRoot SP

Peng Li, Wang Zuhua   

  1. Dept. of Conservative Dentistry and Endodontics, School and Hospital of Stomatology, Peking University, Beijing 100081, China
  • Received:2017-03-12 Revised:2017-08-01 Published:2018-01-15
  • Supported by:
    This study was supported by New Medical Technology Program of Peking University Hospital of Stomatology (PKUS-SNCT-15A07).

摘要: 根管治疗的疗效和预后与根管封闭剂的选择密切相关,iRoot SP作为一种新型生物陶瓷根管封闭剂,因其优越的理化性质和生物学性能而被用于根管充填。iRoot SP的相关性能是学者们研究的热点之一。本文就国内外近年来iRoot SP理化性质和生物学性能研究现状进行了总结。

关键词: iRoot SP, 根管封闭剂, 理化性质, 生物学性能

Abstract: The clinical effects and prognosis of root canal treatment have close relation to the type of the root canal sealer. iRoot SP is a new bioceramic root canal sealer, has been recommended for endodontic obturation because of its superior physicochemical properties and biological performance. The related studies are focused on the characters of iRoot SP. The essay mainly summarizes the current state of physicochemical properties and biological performance research on iRoot SP.

Key words: iRoot SP, root canal sealer, physicochemical properties, biological performance


  • R781.05
[1]高学军, 岳林. 牙体牙髓病学[M]. 2版. 北京: 北京大学医学出版社, 2013:397-399. Gao XJ, Yue L. Cariology, endodontology and operative dentistry[M]. 2nd ed. Beijing: Peking University Medical Press, 2013:397-399.
[2]Zhou HM, Shen Y, Zheng W, et al. Physical proper-ties of 5 root canal sealers[J]. J Endod, 2013, 39(10): 1281-1286.
[3]Ersahan S, Aydin C. Solubility and apical sealing characteristics of a new calcium silicate-based root canal sealer in comparison to calcium hydroxide-, methacrylate resin- and epoxy resin-based sealers[J]. Acta Odontol Scand, 2013, 71(3/4):857-862.
[4]Koch KA, Brave D. EndoSequence: melding endo-dontics with restorative dentistry, part 3[J]. Dent Today, 2009, 28(3):88, 90, 92 passim.
[5]Duarte MA, Ordinola-Zapata R, Bernardes RA, et al. Influence of calcium hydroxide association on the physical properties of AH Plus[J]. J Endod, 2010, 36(6):1048-1051.
[6]Qu W, Bai W, Liang YH, et al. Influence of warm vertical compaction technique on physical properties of root canal sealers[J]. J Endod, 2016, 42(12):1829- 1833.
[7]Koch K, Brave D, Nasseh AA. A review of bioce-ramic technology in endodontics[J]. Roots, 2012(4): 6-12.
[8]Xuereb M, Vella P, Damidot D, et al. In situ assess-ment of the setting of tricalcium silicate-based sealers using a dentin pressure model[J]. J Endod, 2015, 41(1):111-124.
[9]Candeiro GT, Correia FC, Duarte MA, et al. Eva-luation of radiopacity, pH, release of calcium ions, and flow of a bioceramic root canal sealer[J]. J Endod, 2012, 38(6):842-845.
[10]Kara Tuncer A, Tuncer S, Gökyay SS. Correlation between sealer penetration into dentinal tubules and bond strength of two new calcium silicate-based and an epoxy resin-based, endodontic sealer[J]. J Adhes Sci Technol, 2014, 28(7):702-710.
[11]Okşan T, Aktener BO, Sen BH, et al. The penetration of root canal sealers into dentinal tubules. A scan-ning electron microscopic study[J]. Int Endod J, 1993, 26(5):301-305.
[12]Shokouhinejad N, Gorjestani H, Nasseh AA, et al. Push-out bond strength of gutta-percha with a new bioceramic sealer in the presence or absence of smear layer[J]. Aust Endod J, 2013, 39(3):102-106.
[13]Elbatouty KM, Ibrahim DY, Youniss WN. In vitro bond strength of bioceramic root canal sealer in comparison to resin-based and eugenol-based root canal sealers[J]. ENDO-Endod Pract Today, 2015, 9(1):59-63.
[14]DeLong C, He J, Woodmansey KF. The effect of ob-turation technique on the push-out bond strength of calcium silicate sealers[J]. J Endod, 2015, 41(3):385- 388.
[15]Gade VJ, Belsare LD, Patil S, et al. Evaluation of push-out bond strength of endosequence BC sealer with lateral condensation and thermoplasticized technique: an in vitro study[J]. J Conserv Dent, 2015, 18(2):124-127.
[16]Shokouhinejad N, Hoseini A, Gorjestani H, et al. The effect of different irrigation protocols for smear layer removal on bond strength of a new bioceramic sealer[J]. Iran Endod J, 2013, 8(1):10-13.
[17]Ozkocak I, Sonat B. Evaluation of effects on the adhesion of various root canal sealers after Er:YAG laser and irrigants are used on the dentin surface[J]. J Endod, 2015, 41(8):1331-1336.
[18]Taşdemir T, Er K, Çelik D, et al. Bond strength of calcium silicate-based sealers to dentine dried with different techniques[J]. Med Princ Pract, 2014, 23 (4):373-376.
[19]Lee BS, Wang CY, Fang YY, et al. A novel urethane acrylate-based root canal sealer with improved degree of conversion, cytotoxicity, bond strengths, solubility, and dimensional stability[J]. J Endod, 2011, 37(2): 246-249.
[20]Hegde V, Arora S. Effect of intracanal medicaments on push-out bond strength of Smart-Seal system[J]. J Conserv Dent, 2015, 18(5):414-418.
[21]Neelakantan P, Nandagopal M, Shemesh H, et al. The effect of root dentin conditioning protocols on the push-out bond strength of three calcium silicate sealers[J]. Int J Adhes Adhes, 2015, 60(4):104-108.
[22]Zhang W, Li Z, Peng B. Ex vivo cytotoxicity of a new calcium silicate-based canal filling material[J]. Int Endod J, 2010, 43(9):769-774.
[23]Mukhtar-Fayyad D. Cytocompatibility of new bio-ceramic-based materials on human fibroblast cells (MRC-5)[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 112(6):e137-e142.
[24]Zhou HM, Du TF, Shen Y, et al. In vitro cytotoxicity of calcium silicate-containing endodontic sealers[J]. J Endod, 2015, 41(1):56-61.
[25]Chang SW, Lee SY, Kang SK, et al. In vitro biocom-patibility, inflammatory response, and osteogenic potential of 4 root canal sealers: Sealapex, Sankin apatite root sealer, MTA Fillapex, and iRoot SP root canal sealer[J]. J Endod, 2014, 40(10):1642-1648.
[26]Güven EP, Taşlı PN, Yalvac ME, et al. In vitro com-parison of induction capacity and biomineralization ability of mineral trioxide aggregate and a biocera-mic root canal sealer[J]. Int Endod J, 2013, 46(12): 1173-1182.
[27]Güven EP, Yalvaç ME, Kayahan MB, et al. Human tooth germ stem cell response to calcium-silicate based endodontic cements[J]. J Appl Oral Sci, 2013, 21(4):351-357.
[28]Candeiro GT, Moura-Netto C, D’Almeida-Couto RS, et al. Cytotoxicity, genotoxicity and antibacterial effectiveness of a bioceramic endodontic sealer[J]. Int Endod J, 2015. [Epub ahead of print]
[29]Bósio CC, Felippe GS, Bortoluzzi EA, et al. Subcu-taneous connective tissue reactions to iRoot SP, mi-neral trioxide aggregate (MTA) Fillapex, DiaRoot BioAggregate and MTA[J]. Int Endod J, 2014, 47(7):667-674.
[30]Zhang W, Peng B. Tissue reactions after subcu-taneous and intraosseous implantation of iRoot SP, MTA and AH Plus[J]. Dent Mater J, 2015, 34(6): 774-780.
[31]Ruparel NB, Ruparel SB, Chen PB, et al. Direct effect of endodontic sealers on trigeminal neuronal activity[J]. J Endod, 2014, 40(5):683-687.
[32]Zhang H, Shen Y, Ruse ND, et al. Antibacterial acti-vity of endodontic sealers by modified direct contact test against Enterococcus faecalis [J]. J Endod, 2009, 35(7):1051-1055.
[33]McMichen FR, Pearson G, Rahbaran S, et al. A comparative study of selected physical properties of five root-canal sealers[J]. Int Endod J, 2003, 36(9): 629-635.
[34]Thian ES, Huang J, Best SM, et al. The response of osteoblasts to nanocrystalline silicon-substituted hy-droxyapatite thin films[J]. Biomaterials, 2006, 27 (13):2692-2698.
[35]Stock CJ. Calcium hydroxide: root resorption and perio-endo lesions[J]. Br Dent J, 1985, 158(9):325- 334.
[36]Zhang W, Li Z, Peng B. Effects of iRoot SP on mine-ralization-related genes expression in MG63 cells[J]. J Endod, 2010, 36(12):1978-1982.
[37]Han L, Okiji T. Bioactivity evaluation of three cal-cium silicate-based endodontic materials[J]. Int Endod J, 2013, 46(9):808-814.
[38]岳林, 高学军. 根管治疗中的感染控制[J]. 中华口腔医学杂志, 2007, 42(10):577-580. Yue L, Gao XJ. Infection control in root canal the-rapy[J]. Chin J Stomatol, 2007, 42(10):577-580.
[39]Stuart CH, Schwartz SA, Beeson TJ, et al. Enteroco-ccus faecalis : its role in root canal treatment failure and current concepts in retreatment[J]. J Endod, 2006, 32(2):93-98.
[40]Mato R, de Lencastre H, Roberts RB, et al. Multi-plicity of genetic backgrounds among vancomycin-resistant Enterococcus faecium isolates recovered from an outbreak in a New York City hospital[J]. Microb Drug Resist, 1996, 2(3):309-317.
[41]Wang Z, Shen Y, Haapasalo M. Dentin extends the antibacterial effect of endodontic sealers against Enterococcus faecalis biofilms[J]. J Endod, 2014, 40(4):505-508.
[42]Zhang H, Shen Y, Ruse ND, et al. Antibacterial acti-vity of endodontic sealers by modified direct contact test against Enterococcus faecalis [J]. J Endod, 2009, 35(7):1051-1055.
[43]Du T, Wang Z, Shen Y, et al. Combined antibacterial effect of sodium hypochlorite and root canal sealers against Enterococcus faecalis biofilms in dentin canals[J]. J Endod, 2015, 41(8):1294-1298.
[44]Sen BH, Piskin B, Demirci T. Observation of bac-teria and fungi in infected root canals and dentinal tubules by SEM[J]. Endod Dent Traumatol, 1995, 11(1):6-9.
[45]Siqueira JF, Rôças IN, Moraes SR, et al. Direct amp-lification of rRNA gene sequences for identification of selected oral pathogens in root canal infections[J]. Int Endod J, 2002, 35(4):345-351.
[46]Peciuliene V, Reynaud AH, Balciuniene I, et al. Iso-lation of yeasts and enteric bacteria in root-filled teeth with chronic apical periodontitis[J]. Int Endod J, 2001, 34(6):429-434.
[47]Nair PN, Sjögren U, Krey G, et al. Intraradicular bacteria and fungi in root-filled, asymptomatic hu-man teeth with therapy-resistant periapical lesions: a long-term light and electron microscopic follow-up study[J]. J Endod, 1990, 16(12):580-588.
[48]Waltimo TM, Sirén EK, Torkko HL, et al. Fungi in therapy-resistant apical periodontitis[J]. Int Endod J, 1997, 30(2):96-101.
[49]Ozcan E, Yula E, Arslanoğlu Z, et al. Antifungal activity of several root canal sealers against Candida albicans [J]. Acta Odontol Scand, 2013, 71(6):1481- 1485.
[50]Celikten B, Uzuntas CF, Gulsahi K. Resistance to fracture of dental roots obturated with different ma-terials[J]. Biomed Res Int, 2015, 2015:591031.
[51]Dudeja C, Taneja S, Kumari M, et al. An in vitro comparison of effect on fracture strength, pH and calcium ion diffusion from various biomimetic mate-rials when used for repair of simulated root resorp-tion defects[J]. J Conserv Dent, 2015, 18(4):279- 283.
[52]Topçuoğlu HS, Tuncay Ö, Karataş E, et al. In vitro fracture resistance of roots obturated with epoxy resin-based, mineral trioxide aggregate-based, and bioceramic root canal sealers[J]. J Endod, 2013, 39 (12):1630-1633.
[53]Hegde V, Arora S. Fracture resistance of roots obtu-rated with novel hydrophilic obturation systems[J]. J Conserv Dent, 2015, 18(3):261-264.
[54]Ribeiro FC, Souza-Gabriel AE, Marchesan MA, et al. Influence of different endodontic filling materials on root fracture susceptibility[J]. J Dent, 2008, 36 (1):69-73.
[1] 颜愈佳,邹玲. 生物陶瓷类根管封闭剂的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 578-585.
[2] 张曦丹,孙吉宇,付馨靓,甘雪琦. 介孔硅酸钙纳米材料在牙体牙髓及颅颌面修复领域的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 476-482.
[3] 孙莉青,郭宜青,杨爱华,肖文林,孙慧斌. 3种根管充填方法对不同类型根管根尖封闭性的影响研究[J]. 国际口腔医学杂志, 2021, 48(6): 629-634.
[4] 宁晨曦,李霞. 根管封闭剂影响牙根抗折性的研究进展[J]. 国际口腔医学杂志, 2020, 47(6): 711-716.
[5] 刘志东,任吉芳,. 根管封闭剂基因毒性的检测[J]. 国际口腔医学杂志, 2008, 35(S1): -.
[6] 马红综述 章非敏审校. 牙科复合树脂生物学性能的临床和实验室研究[J]. 国际口腔医学杂志, 2008, 35(2): 210-210~212.
Full text



[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .