Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (1): 63-67.doi: 10.7518/gjkq.2020003

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Research advances in SMO gene mutation in ameloblastoma

He Youya,Ji Tong()   

  1. Dept. of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai 200011, China
  • Received:2019-04-28 Revised:2019-10-12 Online:2020-01-01 Published:2020-01-01
  • Contact: Youya He,Tong Ji E-mail:jitong70@hotmail.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81671009)

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Abstract:

The SMO protein encoded by the smoothened oncogene SMO is a crucial signal converter in the sonic hedgehog (SHH) signalling pathway. This signalling pathway is closely related to the occurrence and development of a variety of human tumours. The abnormally activated SHH signalling pathway leads to tumorigenesis by affecting cell proliferation, differentiation and apoptosis. The study found that in the ameloblastoma, the SMO gene is the second most common mutated gene in addition to the BRAF gene, and this high mutation makes the SMO gene a hotspot in ameloblastoma molecular pathology. Many studies confirmed that the SMO gene mutations are related to the clinical features of ameloblastoma, such as location, histology, age and prognosis. These findings provided new therapeutic ideas for targeted therapy of ameloblastoma. This paper reviewed the research progress of the SMO gene mutations in ameloblastoma and their potential clinical significance.

Key words: SMO gene, sonic hedgehog signalling pathway, ameloblastoma, gene mutation

CLC Number: 

  • Q754

TrendMD: 
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