Int J Stomatol

Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (3): 367-369.doi: 10.3969/j.issn.1673-5749.2011.03.034

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Urokinase-type plasminogen activator and p38 mitogen-activated protein kinase signaling pathway in the invasion of head and neck tumor

ZHONG Yi, WANG Li, CHEN Xin-ming.   

  1. Dept. of Pathology, College of Stomatology, Wuhan University, Wuhan 430079, China
  • Received:2010-08-18 Revised:2010-12-16 Online:2011-05-20 Published:2011-05-20

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Abstract:

The degradation of extracellular matrix is an important prerequisite in tumor oncogenesis and invasion. Studies have shown that urokinase-type plasminogen activator（uPA） plays an important role in the degradation of extracellular matrix. It has been suggested that p38 mitogen-activated protein kinase（MAPK） signaling pathway can be involved in tumor invasion by regulating uPA expression. In this article, the research of p38MAPK-signaling pathway and uPA in the invasion of head and neck tumor are reviewed.

Key words: head and neck tumor, urokinase-type plasminogen activator, p38 mitogen-activated protein kinase signaling pathway


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