国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (6): 707-711.doi: 10.7518/gjkq.2017.06.016

• 综述 • 上一篇    下一篇

A型肉毒杆菌毒素在口腔颌面部的临床应用

佘杨杨, 农晓琳   

  1. 广西医科大学口腔医学院•附属口腔医院口腔颌面外科 南宁 530021
  • 收稿日期:2017-02-06 修回日期:2017-05-03 出版日期:2017-11-01 发布日期:2017-11-01
  • 通讯作者: 农晓琳,教授,博士,Email:xnong@gxmu.edu.cn
  • 作者简介:佘杨杨,硕士,Email:sheyangyang7@163.com
  • 基金资助:
    广西科学研究与技术开发计划课题(桂科能14123006-2); 广西研究生教育创新计划项目(201010598RY10)

Clinical application of botulinum toxin type A in oral and maxillofacial region

She Yangyang, Nong Xiaolin.   

  1. Dept. of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Guangxi Medical University, Nanning 530021, China
  • Received:2017-02-06 Revised:2017-05-03 Online:2017-11-01 Published:2017-11-01
  • Supported by:
    This study was supported by Scientific Research and Technology Development Project of Guangxi(14123006-2) and Innovation Project of Guangxi Graduate Education(201010598RY10).

摘要: A型肉毒杆菌毒素(BTX-A)是肉毒杆菌产生的一种细菌外毒素,通过抑制神经-肌肉接头处乙酰胆碱的释放而发挥作用。近年来研究发现,BTX-A可应用于口腔颌面部整形美容及一些口腔疾病的治疗,为口腔疾病替代治疗提供了新方法和新方向。本文综述了BTX-A的作用机制、在口腔颌面部的临床应用、禁忌证、操作注意事项、并发症及治疗。

关键词: A型肉毒杆菌毒素, 口腔颌面部, 临床应用

Abstract: Botulinum toxin type A(BTX-A) is a kind of exotoxin produced by the bacterium Clostridium botulinum which works by inhibiting the release of acetylcholine at the neuromuscular junction. Recent studies have found that BTX-A can be used in the oral and maxillofacial plastic surgery and the treatment of some oral diseases, providing a new method and a new direction for alternative treatment of oral diseases. The present review focuses on the mechanism, clinical application in the oral and maxillofacial region, operation cautions, contraindications and treatment of BTX-A.

Key words: botulinum toxin type A, oral and maxillofacial region, clinical application

中图分类号: 

  • R782
[1] Lam SM. The basic science of botulinum toxin[J]. Fa-cial Plast Surg Clin North Am, 2003, 11(4):431-438.
[2] Niamtu J. Botulinum toxin A: a review of 1 085 oral and maxillofacial patient treatments[J]. J Oral Maxi-llofac Surg, 2003, 61(3):317-324.
[3] Jaspers GW, Pijpe J, Jansma J. The use of botulinum toxin type A in cosmetic facial procedures[J]. Int J Oral Maxillofac Surg, 2011, 40(2):127-133.
[4] Semchyshyn N, Sengelmann RD. Botulinum toxin A treatment of perioral rhytides[J]. Dermatol Surg, 2003, 29(5):490-495.
[5] Suber JS, Dinh TP, Prince MD, et al. Onabotulinum-toxinA for the treatment of a “gummy smile”[J]. Aesthet Surg J, 2014, 34(3):432-437.
[6] Hwang WS, Hur MS, Hu KS, et al. Surface anatomy of the lip elevator muscles for the treatment of gum-my smile using botulinum toxin[J]. Angle Orthod, 2009, 79(1):70-77.
[7] Chang CS, Wallace CG, Hsiao YC, et al. Botulinum toxin to improve results in cleft lip repair[J]. Plast Reconstr Surg, 2014, 134(3):511-516.
[8] Shaarawy E, Hegazy RA, Abdel Hay RM. Intralesio-nal botulinum toxin type A equally effective and bet-ter tolerated than intralesional steroid in the treat-ment of keloids: a randomized controlled trial[J]. J Cosmet Dermatol, 2015, 14(2):161-166.
[9] Lee SH, Wee SH, Kim HJ, et al. Abobotulinum toxin A and onabotulinum toxin A for masseteric hyper-trophy: a split-face study in 25 Korean patients[J]. J Dermatolog Treat, 2013, 24(2):133-136.
[10] Wei J, Xu H, Dong J, et al. Prolonging the duration of masseter muscle reduction by adjusting the masti-catory movements after the treatment of masseter mus-cle hypertrophy with botulinum toxin type a injection [J]. Dermatol Surg, 2015, 41(Suppl 1):S101-S109.
[11] Bae JH, Choi DY, Lee JG, et al. The risorius muscle: anatomic considerations with reference to botulinum neurotoxin injection for masseteric hypertrophy[J]. Dermatol Surg, 2014, 40(12):1334-1339.
[12] Qian W, Zhang YK, Lv W, et al. Application of local injection of botulinum toxin A in cosmetic patients with congenital drooping mouth corner[J]. Aesthetic Plast Surg, 2016, 40(6):926-930.
[13] Pihut M, Ferendiuk E, Szewczyk M, et al. The effi-ciency of botulinum toxin type A for the treatment of masseter muscle pain in patients with temporoman-dibular joint dysfunction and tension-type headache [J]. J Headache Pain, 2016, 17(1):29.
[14] Ernberg M, Hedenberg-Magnusson B, List T, et al. Efficacy of botulinum toxin type A for treatment of persistent myofascial TMD pain: a randomized, con-trolled, double-blind multicenter study[J]. Pain, 2011, 152(9):1988-1996.
[15] Stark TR, Perez CV, Okeson JP. Recurrent TMJ dis-location managed with botulinum toxin type a injec-tions in a pediatric patient[J]. Pediatr Dent, 2015, 37 (1):65-69.
[16] Oztel M, Bilski WM, Bilski A. Botulinum toxin used to treat recurrent dislocation of the temporomandibular joint in a patient with osteoporosis[J]. Br J Oral Maxi-llofac Surg, 2017, 55(1):e1-e2.
[17] Zhang H, Lian Y, Ma Y, et al. Two doses of botu-linum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlledtrial [J]. J Headache Pain, 2014, 15(1):65.
[18] Al-Wayli H. Treatment of chronic pain associated with nocturnal bruxism with botulinum toxin. A prospective and randomized clinical study[J]. J Clin Exp Dent, 2017, 9(1):e112-e117.
[19] Barbero P, Busso M, Artusi CA, et al. Ultrasound-guided botulinum toxin-A injections: a method of treating sialorrhea[J]. J Vis Exp, 2016(117). doi:10.3791/54606.
[20] Sorgun MH, Yilmaz R, Akin YA, et al. Botulinum toxin injections for the treatment of hemifacial spasm over 16 years[J]. J Clin Neurosci, 2015, 22(8):1319-1325.
[21] Li YJ, Huang Y, Ding Q, et al. Evaluation of concen-trations of botulinum toxin A for the treatment of hemifacial spasm: a randomized double-blind cross-over trial[J]. Genet Mol Res, 2015, 14(1):1136-1144.
[22] Alexoudi A, Dalivigka Z, Siatouni A, et al. Oroman-dibular dystonia: a case report of the lateral pterygoid muscle involvement and treatment with botulinum toxin a[J]. Clin Pract, 2016, 6(3):862.
[23] Melville JC, Stackowicz DJ, Jundt JS, et al. Use of Botox(OnabotulinumtoxinA) for the treatment of parotid sialocele and fistula after extirpation of buccal squamous cell carcinoma with immediate reconstruc-tion using microvascular free flap: a report of 3 cases [J]. J Oral Maxillofac Surg, 2016, 74(8):1678-1686.
[24] Kayikçioğlu A, Erk Y, Mavili E, et al. Botulinum toxin in the treatment of zygomatic fractures[J]. Plast Reconstr Surg, 2003, 111(1):341-346.
[25] Akbay E, Cevik C, Damlar I, et al. Treatment of displaced mandibular condylar fracture with botuli-num toxin A[J]. Auris Nasus Larynx, 2014, 41(2): 219-221.
[1] 吴嘉馨,程兴群,吴红崑. 透明质酸在修复龈乳头退缩中的临床应用进展[J]. 国际口腔医学杂志, 2023, 50(3): 347-352.
[2] 戴清仪,郝昊,华成舸,黄波,杨征. 口腔及颅颌面部常见运动防护用具的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 366-373.
[3] 木合森·牙生江,买买提吐逊·吐尔地. 带线锚钉在口腔颌面外科的应用[J]. 国际口腔医学杂志, 2023, 50(1): 114-119.
[4] 陈克难,郭传瑸. 可降解医用镁基金属生物材料的研究进展[J]. 国际口腔医学杂志, 2021, 48(3): 322-328.
[5] 刘琳,周婕妤,吴亚菲,赵蕾. 益生菌生态调节在牙周病防治中的应用[J]. 国际口腔医学杂志, 2020, 47(2): 131-137.
[6] 胡竹林,赵诣,李茵. 口腔龈沟液生物标志物的检测分析现状及临床应用前景展望[J]. 国际口腔医学杂志, 2019, 46(3): 308-315.
[7] 丁杰, 宋光泰. 微创技术在儿童龋病治疗中的应用[J]. 国际口腔医学杂志, 2018, 45(4): 473-479.
[8] 李晓, 季彤. 颌面头颈部骨肉瘤化学治疗的研究进展[J]. 国际口腔医学杂志, 2017, 44(1): 83-86.
[9] 郭文豪,游梦,罗晶晶,王凯利,王虎,郑广宁. 4例口腔颌面部非霍奇金淋巴瘤的影像学表现[J]. 国际口腔医学杂志, 2016, 43(2): 146-150.
[10] 罗志强, 南晓梅 叶钟泰. 2 085例口腔颌面部肿瘤疾病构成比分析[J]. 国际口腔医学杂志, 2015, 42(6): 635-639.
[11] 吴幸晨 朱亚琴. 自调节根管锉的特性和临床应用评价[J]. 国际口腔医学杂志, 2013, 40(6): 764-768.
[12] 于婷婷 宋光保. T-Scan系统的特点及其临床应用[J]. 国际口腔医学杂志, 2013, 40(1): 113-116.
[13] 边翔1综述李志韧2 杨永进2 沈焕2审校. Bolton 指数指导正畸的临床应用[J]. 国际口腔医学杂志, 2012, 39(5): 646-648.
[14] 陈兵. 太极扣附着体义齿的临床应用[J]. 国际口腔医学杂志, 2010, 37(3): 265-265~267.
[15] 顾敏综述 顾卫平审校. 排龈术的临床应用[J]. 国际口腔医学杂志, 2010, 37(3): 344-344~347.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .