国际口腔医学杂志

国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (6): 642-646.doi: 10.7518/gjkq.2017.06.004

• 微生物专栏 • 上一篇    下一篇

牙周微生物与代谢综合征关系的研究进展

何林林, 杨卓, 刘程程, 丁一   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心,四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2016-11-29 修回日期:2017-07-09 出版日期:2017-11-01 发布日期:2017-11-01
  • 通讯作者: 丁一,教授,博士,Email：yiding2000@126.com
  • 作者简介:何林林,硕士,Email：1040809227@qq.com
  • 基金资助:
    国家自然科学基金（81600871）; 国家临床重点专科基金（2010）; 四川大学青年教师科研启动基金（2016SCU11056）

Research progress on the relationship of periodontal microbes and metabolic syndrome

He Linlin, Yang Zhuo, Liu Chengcheng, Ding Yi.   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-11-29 Revised:2017-07-09 Online:2017-11-01 Published:2017-11-01
  • Supported by:
    This work was supported by National Natural Science Foundation of China(81600871), National Key Clinical Specialist Foundation(2010) and The Scientific Research Foundation for Young Teachers, Sichuan University(2016SCU11056).

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摘要： 代谢综合征是一组以蛋白质、脂肪和碳水化合物等物质发生代谢紊乱为特征的症候群,被公认为心血管疾病、糖尿病的危险因素。已有研究表明牙周炎与代谢综合征各症候之间存在不同程度的关联。本文将牙周微生物与代谢综合征各症候的关系及潜在的相关机制（致炎通路和氧化应激）进行综述,以期为代谢综合征防治的研究提供新的思路。

关键词: 牙周微生物, 代谢综合征, 高脂血症, 血栓前状态, 胰岛素抵抗, 促炎症状态, 腹部肥胖

Abstract: A metabolic syndrome is characterized by symptoms of metabolic disorders, such as proteins, fats, and carbohydrates associated with increased risks of cardiovascular diseases and diabetes mellitus. Recent evidence has proposed the relationship between periodontitis and metabolic syndrome. In this review, progress on the role of inflammation and oxidative stress and the relationship of oral microbes with the main characteristics of metabolic syndrome is presented to provide new insights into the prevention and intervention of metabolic syndrome.

Key words: periodontal microbiome, metabolic syndrome, hyperlipidemia, prothrombotic state, insulin resistance, proinflammatory state, abdominal obesity

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