国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (6): 706-710.doi: 10.7518/gjkq.2020107

• 综述 • 上一篇    下一篇

宿主调节治疗在牙周病治疗中的研究进展

陈亮(),丁一,孟姝()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2020-03-05 修回日期:2020-07-10 出版日期:2020-11-01 发布日期:2020-11-06
  • 通讯作者: 孟姝
  • 作者简介:陈亮,硕士,Email: clworkzone@126.com
  • 基金资助:
    国家重点基础研究发展计划(973计划项目)(2013CBA-01705-1)

Research progress of host modulation therapy in the treatment of periodontal diseases

Chen Liang(),Ding Yi,Meng Shu()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-03-05 Revised:2020-07-10 Online:2020-11-01 Published:2020-11-06
  • Contact: Shu Meng
  • Supported by:
    National Key Basic Research and Development Program (973 Program)(2013CBA-01705-1)

摘要:

宿主调节治疗(HMT)是一种治疗概念,通过调节宿主免疫炎症反应来减少组织破坏从而治疗炎症性疾病。HMT已被用于治疗骨质疏松症和关节炎,近年来在口腔医学中的应用引起了广泛关注。目前主要研究用于牙周治疗领域的宿主调节药物包括四环素族药物、非甾体类抗炎药、双膦酸盐、促炎细胞因子拮抗剂、脂氧素等。本文就这些药物在牙周治疗的研究进展进行综述。

关键词: 宿主调节治疗, 牙周疾病, 亚抗菌剂量多西环素, 化学改性四环素, 脂氧素

Abstract:

Host modulation therapy (HMT) is a therapeutic concept that treats inflammatory diseases by modulating host immune inflammatory responses to reduce tissue destruction. HMT has been used to treat osteoporosis and arthritis, and its application in stomatology has attracted widespread attention in recent years. This article reviews the current research progress of host-modulating drugs in the field of periodontal therapy, mainly including tetracycline drugs, non-steroidal- anti-inflammatory drugs, bisphosphonates, pro-inflammatory cytokine antagonists, and lipoxins.

Key words: host modulation therapy, periodontal diseases, sub-antimicrobial dose doxycycline, chemically modified tetracycline, lipoxins

中图分类号: 

  • R781.4
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