国际口腔医学杂志

国际口腔医学杂志 ›› 2020, Vol. 47 ›› Issue (6): 706-710.doi: 10.7518/gjkq.2020107

• 综述 • 上一篇    下一篇

宿主调节治疗在牙周病治疗中的研究进展

陈亮(),丁一,孟姝()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2020-03-05 修回日期:2020-07-10 出版日期:2020-11-01 发布日期:2020-11-06
  • 通讯作者: 孟姝
  • 作者简介:陈亮,硕士,Email： clworkzone@126.com
  • 基金资助:
    国家重点基础研究发展计划(973计划项目)(2013CBA-01705-1)

Research progress of host modulation therapy in the treatment of periodontal diseases

Chen Liang(),Ding Yi,Meng Shu()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-03-05 Revised:2020-07-10 Online:2020-11-01 Published:2020-11-06
  • Contact: Shu Meng
  • Supported by:
    National Key Basic Research and Development Program (973 Program)(2013CBA-01705-1)

RichHTML

18

PDF (PC)

215

摘要：

宿主调节治疗（HMT）是一种治疗概念,通过调节宿主免疫炎症反应来减少组织破坏从而治疗炎症性疾病。HMT已被用于治疗骨质疏松症和关节炎,近年来在口腔医学中的应用引起了广泛关注。目前主要研究用于牙周治疗领域的宿主调节药物包括四环素族药物、非甾体类抗炎药、双膦酸盐、促炎细胞因子拮抗剂、脂氧素等。本文就这些药物在牙周治疗的研究进展进行综述。

关键词: 宿主调节治疗, 牙周疾病, 亚抗菌剂量多西环素, 化学改性四环素, 脂氧素

Abstract:

Host modulation therapy (HMT) is a therapeutic concept that treats inflammatory diseases by modulating host immune inflammatory responses to reduce tissue destruction. HMT has been used to treat osteoporosis and arthritis, and its application in stomatology has attracted widespread attention in recent years. This article reviews the current research progress of host-modulating drugs in the field of periodontal therapy, mainly including tetracycline drugs, non-steroidal- anti-inflammatory drugs, bisphosphonates, pro-inflammatory cytokine antagonists, and lipoxins.

Key words: host modulation therapy, periodontal diseases, sub-antimicrobial dose doxycycline, chemically modified tetracycline, lipoxins

中图分类号: 

  • R781.4
[1] Preshaw PM. Host response modulation in perio-dontics[J]. Periodontol 2000, 2008,48:92-110.
doi: 10.1111/j.1600-0757.2008.00252.x pmid: 18715360
[2] Harvey JD. Periodontal microbiology[J]. Dent Clin N Am, 2017,61(2):253-269.
doi: 10.1016/j.cden.2016.11.005 pmid: 28317565
[3] Cotts KG, Cifu AS. Treatment of osteoporosis[J]. JAMA, 2018,319(10):1040-1041.
pmid: 29536084
[4] Bullock J, Rizvi SAA, Saleh AM, et al. Rheumatoid arthritis: a brief overview of the treatment[J]. Med Princ Pract, 2018,27(6):501-507.
doi: 10.1159/000493390 pmid: 30173215
[5] Aletaha D, Smolen JS. Diagnosis and management of rheumatoid arthritis: a review[J]. JAMA, 2018,320(13):1360-1372.
pmid: 30285183
[6] Shahi RG, Albuquerque MTP, Münchow EA, et al. Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental im- plant coating[J]. Odontology, 2017,105(3):354-363.
doi: 10.1007/s10266-016-0268-z pmid: 27585669
[7] Golub LM, Lee HM. Periodontal therapeutics: current host-modulation agents and future directions[J]. Periodontol 2000, 2020,82(1):186-204.
pmid: 31850625
[8] Alyousef AA, Divakar DD, Muzaheed. Chemically modified tetracyclines an emerging host modulator in chronic periodontitis patients: a randomized, double-blind, placebo-controlled, clinical trial[J]. Microb Pathog, 2017,110:279-284.
pmid: 28687322
[9] Preshaw PM. Host modulation therapy with anti-inflammatory agents[J]. Periodontol 2000, 2018,76(1):131-149.
doi: 10.1111/prd.12148 pmid: 29193331
[10] Preshaw PM, Hefti AF, Bradshaw MH. Adjunctive subantimicrobial dose doxycycline in smokers and non-smokers with chronic periodontitis[J]. J Clin Periodontol, 2005,32(6):610-616.
doi: 10.1111/j.1600-051X.2005.00728.x pmid: 15882219
[11] Vieira GHA, Messora MR, Moura JMT, et al. Sub-antimicrobial doses of doxycycline decreased bone loss related to ligature-induced periodontitis in hy-pertensive rats[J]. Arch Oral Biol, 2019,101:77-84.
doi: 10.1016/j.archoralbio.2019.03.011 pmid: 30904828
[12] Wang N, Tian X, Chen Y, et al. Low dose doxycycline decreases systemic inflammation and improves gly-cemic control, lipid profiles, and islet morphology and function in db/db mice[J]. Sci Rep, 2017,7(1):14707.
pmid: 29089617
[13] Golub LM, Elburki MS, Walker C, et al. Non-anti-bacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases[J]. Int Dent J, 2016,66(3):127-135.
doi: 10.1111/idj.12221 pmid: 27009489
[14] Swamy DN, Sanivarapu S, Moogla S, et al. Chemically modified tetracyclines: the novel host modulating agents[J]. J Indian Soc Periodontol, 2015,19(4):370-374.
pmid: 26392682
[15] Ghangurde AA, Ganji KK, Bhongade ML, et al. Role of chemically modified tetracyclines in the manage-ment of periodontal diseases: a review[J]. Drug Res (Stuttg), 2017,67(5):258-265.
[16] Ozgören O, Develioglu H, Güncü G, et al. The adjunctive effect of tenoxicam during non-surgical periodontal treatment on clinical parameters and gingival crevicular fluid levels of MMP-8 and TNF- α in patients with chronic periodontitis— randomized, double-blind clinical trial[J]. Adv Clin Exp Med, 2014,23(4):559-565.
pmid: 25166440
[17] Oduncuoglu BF, Kayar NA, Haliloglu S, et al. Effects of a cyclic NSAID regimen on levels of gingival crevicular fluid prostaglandin E2 and interleukin-1β: a 6-month randomized controlled clinical trial[J]. Niger J Clin Pract, 2018,21(5):658-666.
doi: 10.4103/njcp.njcp_221_17
[18] Etikala A, Tattan M, Askar H, et al. Effects of NSAIDs on periodontal and dental implant therapy[J]. Com-pend Contin Educ Dent, 2019,40(2):e1-e9.
[19] Dogné JM, Hanson J, Supuran C, et al. Coxibs and cardiovascular side-effects: from light to shadow[J]. Curr Pharm Des, 2006,12(8):971-975.
pmid: 16533164
[20] Hamed R, AbuRezeq A, Tarawneh O. Development of hydrogels, oleogels, and bigels as local drug de-livery systems for periodontitis[J]. Drug Dev Ind Pharm, 2018,44(9):1488-1497.
pmid: 29669437
[21] Akram Z, Abduljabbar T, Kellesarian SV, et al. Efficacy of bisphosphonate as an adjunct to nonsurgical periodontal therapy in the management of perio-dontal disease: a systematic review[J]. Br J Clin Pharmacol, 2017,83(3):444-454.
pmid: 27718252
[22] Üstün K, Erciyas K, Kısacık B, et al. Host modula-tion in rheumatoid arthritis patients with TNF blo-ckers significantly decreases biochemical parameters in periodontitis[J]. Inflammation, 2013,36(5):1171-1177.
doi: 10.1007/s10753-013-9652-9 pmid: 23649513
[23] Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology[J]. Nature, 2014,510(7503):92-101.
doi: 10.1038/nature13479 pmid: 24899309
[24] van Dyke TE. Pro-resolving mediators in the regula-tion of periodontal disease[J]. Mol Aspects Med, 2017,58:21-36.
pmid: 28483532
[25] van Dyke TE, Hasturk H, Kantarci A, et al. Prore-solving nanomedicines activate bone regeneration in periodontitis[J]. J Dent Res, 2015,94(1):148-156.
pmid: 25389003
[26] Elwakeel NM, Hazaa HH. Effect of omega 3 fatty acids plus low-dose aspirin on both clinical and bio-chemical profiles of patients with chronic periodon-titis and type 2 diabetes: a randomized double blind placebo-controlled study[J]. J Periodont Res, 2015,50(6):721-729.
[27] Cantley MD, Bartold PM, Marino V, et al. Histone deacetylase inhibitors and periodontal bone loss[J]. J Periodont Res, 2011,46(6):697-703.
[28] Qin HT, Li HQ, Liu F. Selective histone deacetylase small molecule inhibitors: recent progress and pers-pectives[J]. Expert Opin Ther Pat, 2017,27(5):621-636.
pmid: 28033734
[29] Yang H, Wen Q, Xue J, et al. Alveolar bone re-generation potential of a traditional Chinese medicine, Bu-Shen-Gu-Chi-Wan, in experimental periodontitis[J]. J Periodont Res, 2014,49(3):382-389.
[30] 吕宗凯, 郑杨灿, 杨映阳, 等. 补肾固齿丸治疗牙周炎的Meta分析[J]. 中华口腔医学研究杂志(电子版), 2015,9(4):308-312.
Lü ZK, Zheng YC, Yang YY, et al. Effects of bushen-guchiwan on treatment of perio-dontitis: a meta an-alysis[J]. Chin J Stomatol Res (Electron Ed), 2015,9(4):308-312.
[31] Curylofo-Zotti FA, Elburki MS, Oliveira PA, et al. Differential effects of natural curcumin and che-mically modified curcumin on inflammation and bone resorption in model of experimental periodontitis[J]. Arch Oral Biol, 2018,91:42-50.
pmid: 29669267
[32] Corrêa MG, Pires PR, Ribeiro FV, et al. Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats[J]. PLoS One, 2018,13(10):e0204414.
doi: 10.1371/journal.pone.0204414 pmid: 30281626
[33] Sheridan RA, Wang HL, Eber R, et al. Systemic chemotherapeutic agents as adjunctive periodontal therapy: a narrative review and suggested clinical recommendations[J]. J Int Acad Periodontol, 2015,17(4):123-134.
pmid: 26727151
[34] Papapanou PN, Sanz M, Buduneli N, et al. Perio-dontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of perio-dontal and peri-implant diseases and conditions[J]. J Periodontol, 2018,89(Suppl 1):S173-S182.
[1] 白慧敏,张雨薇,孟姝,刘程程. 特异性促炎症消退介质在牙周炎中作用的研究进展[J]. 国际口腔医学杂志, 2022, 49(1): 85-93.
[2] 陈艳艳,彭显,周学东,程磊. 定量光导荧光技术在龋病及牙周疾病诊治中的应用[J]. 国际口腔医学杂志, 2019, 46(6): 699-704.
[3] 朱博文,陈立妹,郭竹玲. NLRP3炎性小体在牙周疾病中的研究进展[J]. 国际口腔医学杂志, 2019, 46(4): 450-455.
[4] 吴冷 王骏 赵蕾 吴亚菲. 核苷酸结合寡聚化结构域样受体热蛋白结构域亚家族成员3炎症小体的活化调节与牙周疾病的关系[J]. 国际口腔医学杂志, 2015, 42(6): 710-714.
[5] 周乔 杨靖梅 徐屹. 脂氧素及其在牙周炎症消退中的作用[J]. 国际口腔医学杂志, 2014, 41(5): 613-616.
[6] 闫秀娟 吴晓光 郗红 王珂 李毅. 二膦酸盐干预牙槽骨吸收及其机制[J]. 国际口腔医学杂志, 2014, 41(4): 424-426.
[7] 陈家俊 董伟 吴亚菲. 影响妊娠期牙周健康状况的因素分析[J]. 国际口腔医学杂志, 2014, 41(2): 165-168.
[8] 王学莹 关为群. 脂氧素A4与炎症性疾病[J]. 国际口腔医学杂志, 2013, 40(3): 334-338.
[9] 赵丹凤 龚启梅综述 凌均棨审校. 游走抑制因子及其在牙周疾病中的作用[J]. 国际口腔医学杂志, 2012, 39(1): 110-112.
[10] 文钦, 冯琛琛综述 丁一审校. 骨转换生化标志物在牙周领域中的应用[J]. 国际口腔医学杂志, 2010, 37(01): 51-55.
[11] 何剑玲1综述 夏娟2审校. 牙周疾病与早产儿及低体重儿相关性的研究进展[J]. 国际口腔医学杂志, 2008, 35(6): 687-687～689.
[12] 刘宗霞,李纾,. 显微计算机辅助断层摄影技术在牙周病学中的应用[J]. 国际口腔医学杂志, 2007, 34(06): 430-432.
[13] 张韶君,张蕴惠. N-乙酰基转移酶基因多态性与牙周病[J]. 国际口腔医学杂志, 2005, 32(02): 93-95.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .