国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (6): 707-711.doi: 10.7518/gjkq.2017.06.016
佘杨杨, 农晓琳
She Yangyang, Nong Xiaolin.
摘要: A型肉毒杆菌毒素(BTX-A)是肉毒杆菌产生的一种细菌外毒素,通过抑制神经-肌肉接头处乙酰胆碱的释放而发挥作用。近年来研究发现,BTX-A可应用于口腔颌面部整形美容及一些口腔疾病的治疗,为口腔疾病替代治疗提供了新方法和新方向。本文综述了BTX-A的作用机制、在口腔颌面部的临床应用、禁忌证、操作注意事项、并发症及治疗。
中图分类号:
[1] Lam SM. The basic science of botulinum toxin[J]. Fa-cial Plast Surg Clin North Am, 2003, 11(4):431-438. [2] Niamtu J. Botulinum toxin A: a review of 1 085 oral and maxillofacial patient treatments[J]. J Oral Maxi-llofac Surg, 2003, 61(3):317-324. [3] Jaspers GW, Pijpe J, Jansma J. The use of botulinum toxin type A in cosmetic facial procedures[J]. Int J Oral Maxillofac Surg, 2011, 40(2):127-133. [4] Semchyshyn N, Sengelmann RD. Botulinum toxin A treatment of perioral rhytides[J]. Dermatol Surg, 2003, 29(5):490-495. [5] Suber JS, Dinh TP, Prince MD, et al. Onabotulinum-toxinA for the treatment of a “gummy smile”[J]. Aesthet Surg J, 2014, 34(3):432-437. [6] Hwang WS, Hur MS, Hu KS, et al. Surface anatomy of the lip elevator muscles for the treatment of gum-my smile using botulinum toxin[J]. Angle Orthod, 2009, 79(1):70-77. [7] Chang CS, Wallace CG, Hsiao YC, et al. Botulinum toxin to improve results in cleft lip repair[J]. Plast Reconstr Surg, 2014, 134(3):511-516. [8] Shaarawy E, Hegazy RA, Abdel Hay RM. Intralesio-nal botulinum toxin type A equally effective and bet-ter tolerated than intralesional steroid in the treat-ment of keloids: a randomized controlled trial[J]. J Cosmet Dermatol, 2015, 14(2):161-166. [9] Lee SH, Wee SH, Kim HJ, et al. Abobotulinum toxin A and onabotulinum toxin A for masseteric hyper-trophy: a split-face study in 25 Korean patients[J]. J Dermatolog Treat, 2013, 24(2):133-136. [10] Wei J, Xu H, Dong J, et al. Prolonging the duration of masseter muscle reduction by adjusting the masti-catory movements after the treatment of masseter mus-cle hypertrophy with botulinum toxin type a injection [J]. Dermatol Surg, 2015, 41(Suppl 1):S101-S109. [11] Bae JH, Choi DY, Lee JG, et al. The risorius muscle: anatomic considerations with reference to botulinum neurotoxin injection for masseteric hypertrophy[J]. Dermatol Surg, 2014, 40(12):1334-1339. [12] Qian W, Zhang YK, Lv W, et al. Application of local injection of botulinum toxin A in cosmetic patients with congenital drooping mouth corner[J]. Aesthetic Plast Surg, 2016, 40(6):926-930. [13] Pihut M, Ferendiuk E, Szewczyk M, et al. The effi-ciency of botulinum toxin type A for the treatment of masseter muscle pain in patients with temporoman-dibular joint dysfunction and tension-type headache [J]. J Headache Pain, 2016, 17(1):29. [14] Ernberg M, Hedenberg-Magnusson B, List T, et al. Efficacy of botulinum toxin type A for treatment of persistent myofascial TMD pain: a randomized, con-trolled, double-blind multicenter study[J]. Pain, 2011, 152(9):1988-1996. [15] Stark TR, Perez CV, Okeson JP. Recurrent TMJ dis-location managed with botulinum toxin type a injec-tions in a pediatric patient[J]. Pediatr Dent, 2015, 37 (1):65-69. [16] Oztel M, Bilski WM, Bilski A. Botulinum toxin used to treat recurrent dislocation of the temporomandibular joint in a patient with osteoporosis[J]. Br J Oral Maxi-llofac Surg, 2017, 55(1):e1-e2. [17] Zhang H, Lian Y, Ma Y, et al. Two doses of botu-linum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlledtrial [J]. J Headache Pain, 2014, 15(1):65. [18] Al-Wayli H. Treatment of chronic pain associated with nocturnal bruxism with botulinum toxin. A prospective and randomized clinical study[J]. J Clin Exp Dent, 2017, 9(1):e112-e117. [19] Barbero P, Busso M, Artusi CA, et al. Ultrasound-guided botulinum toxin-A injections: a method of treating sialorrhea[J]. J Vis Exp, 2016(117). doi:10.3791/54606. [20] Sorgun MH, Yilmaz R, Akin YA, et al. Botulinum toxin injections for the treatment of hemifacial spasm over 16 years[J]. J Clin Neurosci, 2015, 22(8):1319-1325. [21] Li YJ, Huang Y, Ding Q, et al. Evaluation of concen-trations of botulinum toxin A for the treatment of hemifacial spasm: a randomized double-blind cross-over trial[J]. Genet Mol Res, 2015, 14(1):1136-1144. [22] Alexoudi A, Dalivigka Z, Siatouni A, et al. Oroman-dibular dystonia: a case report of the lateral pterygoid muscle involvement and treatment with botulinum toxin a[J]. Clin Pract, 2016, 6(3):862. [23] Melville JC, Stackowicz DJ, Jundt JS, et al. Use of Botox(OnabotulinumtoxinA) for the treatment of parotid sialocele and fistula after extirpation of buccal squamous cell carcinoma with immediate reconstruc-tion using microvascular free flap: a report of 3 cases [J]. J Oral Maxillofac Surg, 2016, 74(8):1678-1686. [24] Kayikçioğlu A, Erk Y, Mavili E, et al. Botulinum toxin in the treatment of zygomatic fractures[J]. Plast Reconstr Surg, 2003, 111(1):341-346. [25] Akbay E, Cevik C, Damlar I, et al. Treatment of displaced mandibular condylar fracture with botuli-num toxin A[J]. Auris Nasus Larynx, 2014, 41(2): 219-221. |
[1] | 吴嘉馨,程兴群,吴红崑. 透明质酸在修复龈乳头退缩中的临床应用进展[J]. 国际口腔医学杂志, 2023, 50(3): 347-352. |
[2] | 戴清仪,郝昊,华成舸,黄波,杨征. 口腔及颅颌面部常见运动防护用具的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 366-373. |
[3] | 木合森·牙生江,买买提吐逊·吐尔地. 带线锚钉在口腔颌面外科的应用[J]. 国际口腔医学杂志, 2023, 50(1): 114-119. |
[4] | 陈克难,郭传瑸. 可降解医用镁基金属生物材料的研究进展[J]. 国际口腔医学杂志, 2021, 48(3): 322-328. |
[5] | 刘琳,周婕妤,吴亚菲,赵蕾. 益生菌生态调节在牙周病防治中的应用[J]. 国际口腔医学杂志, 2020, 47(2): 131-137. |
[6] | 胡竹林,赵诣,李茵. 口腔龈沟液生物标志物的检测分析现状及临床应用前景展望[J]. 国际口腔医学杂志, 2019, 46(3): 308-315. |
[7] | 丁杰, 宋光泰. 微创技术在儿童龋病治疗中的应用[J]. 国际口腔医学杂志, 2018, 45(4): 473-479. |
[8] | 李晓, 季彤. 颌面头颈部骨肉瘤化学治疗的研究进展[J]. 国际口腔医学杂志, 2017, 44(1): 83-86. |
[9] | 郭文豪,游梦,罗晶晶,王凯利,王虎,郑广宁. 4例口腔颌面部非霍奇金淋巴瘤的影像学表现[J]. 国际口腔医学杂志, 2016, 43(2): 146-150. |
[10] | 罗志强, 南晓梅 叶钟泰. 2 085例口腔颌面部肿瘤疾病构成比分析[J]. 国际口腔医学杂志, 2015, 42(6): 635-639. |
[11] | 吴幸晨 朱亚琴. 自调节根管锉的特性和临床应用评价[J]. 国际口腔医学杂志, 2013, 40(6): 764-768. |
[12] | 于婷婷 宋光保. T-Scan系统的特点及其临床应用[J]. 国际口腔医学杂志, 2013, 40(1): 113-116. |
[13] | 边翔1综述李志韧2 杨永进2 沈焕2审校. Bolton 指数指导正畸的临床应用[J]. 国际口腔医学杂志, 2012, 39(5): 646-648. |
[14] | 陈兵. 太极扣附着体义齿的临床应用[J]. 国际口腔医学杂志, 2010, 37(3): 265-265~267. |
[15] | 顾敏综述 顾卫平审校. 排龈术的临床应用[J]. 国际口腔医学杂志, 2010, 37(3): 344-344~347. |
|