国际口腔医学杂志

国际口腔医学杂志 ›› 2016, Vol. 43 ›› Issue (2): 172-176.doi: 10.7518/gjkq.2016.02.013

• 综述 • 上一篇    下一篇

病原相关分子模式和损伤相关分子模式在免疫炎症反应中的作用

丁烨1,任静宜1,于洪强1,周延民1,于维先2   

  1. 1.吉林大学口腔医院种植中心；2.吉林省牙发育及颌骨重塑与再生省重点实验室 长春 130021
  • 收稿日期:2015-10-20 修回日期:2015-12-01 出版日期:2016-03-01 发布日期:2016-03-01
  • 通讯作者: 于维先，教授，博士，Email：yu-wei-xian@163.com
  • 作者简介:丁烨，硕士，Email：619970554@qq.com
  • 基金资助:
    吉林省发展和改革委员会基金（2013C022-4）

Roles of pathogen-associated and damage-associated molecular patterns in immune inflammatory response

Ding Ye1, Ren Jingyi1, Yu Hongqiang1, Zhou Yanmin1, Yu Weixian2   

  1. 1. Dept. of Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China; 2. Key Laboratory of Mechanism of Tooth Development and Jaw Bone Remodeling and Regeneration in Jilin Province, Changchun 130021, China)
  • Received:2015-10-20 Revised:2015-12-01 Online:2016-03-01 Published:2016-03-01

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摘要： 病原相关分子模式（PAMP）和损伤相关分子模式（DAMP）是与免疫学息息相关的两个分子。DAMP是组织或细胞受到损伤和低氧等因素刺激后释放到细胞间或血液循环中的一类物质；PAMP则是病原体上的分子结构。两者均被模式识别受体（PRR）识别引起免疫应答。目前，已经有研究表明，DAMP和PAMP与慢性炎症疾病和自身免疫性疾病有关。本文就PAMP和DAMP分子在免疫炎症反应中的作用作一综述。

关键词: 病原相关分子模式, 损伤相关分子模式, 模式识别受体, 免疫炎症反应, 病原相关分子模式, 损伤相关分子模式, 模式识别受体, 免疫炎症反应

Abstract: Pathogen-associated molecular patterns(PAMP) and damage-associated molecular patterns(DAMP) are two molecules closely linked to immunology. DAMP are defined as a class of substances released to the cell or blood supply upon stimulation by tissue damage, cell hypoxia, or other factors. PAMP form the molecular structure of the pathogen. Both of these molecules are identified by pattern recognition receptors, which leads to the immune response. To date, research shows that DAMP and PAMP are associated with chronic inflammatory and autoimmune diseases. This thesis will summarize the roles of PAMP and DAMP molecules in immune inflammatory response.

Key words: pathogen-associated molecular pattern, damage-associated molecular pattern, pattern recognition receptor, immune inflammatory response, pathogen-associated molecular pattern, damage-associated molecular pattern, pattern recognition receptor, immune inflammatory response

中图分类号: 

  • Q 753
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（本文采编 王晴）
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[2] 吴冷 王骏 赵蕾 吴亚菲. 核苷酸结合寡聚化结构域样受体热蛋白结构域亚家族成员3炎症小体的活化调节与牙周疾病的关系[J]. 国际口腔医学杂志, 2015, 42(6): 710-714.
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