国际口腔医学杂志 ›› 2015, Vol. 42 ›› Issue (1): 24-27.doi: 10.7518/gjkq.2015.01.007

• 论著 • 上一篇    下一篇

肿痛安治疗癌症放射治疗后颞下颌关节疼痛的疗效评价

陈琦 吴芸   

  1. 成都市第三人民医院口腔科 成都 610031
  • 出版日期:2015-01-01 发布日期:2015-01-01
  • 通讯作者: 吴芸,主治医师,博士,Email:cq521328@tom.com
  • 作者简介:陈琦,副主任医师,博士,Email:dentistcharliechan@aliyun.com
  • 基金资助:

    四川省卫生厅科研基础项目(120537)

Therapeutic evaluation of Zhongtongan in the treatment of temporomandibular joint pain after radiotherapy

Chen Qi, Wu Yun   

  1. Dept. of Stomatology, Chengdu Third People’s Hospital, Chengdu 610031, China
  • Online:2015-01-01 Published:2015-01-01

摘要:

目的 评价肿痛安治疗癌症放射治疗后颞下颌关节疼痛的疗效。方法 选择癌症放射治疗后出现颞下颌关节疼痛的患者,试验组给予肿痛安口服,对照组分别给予布洛芬和维生素E口服,记录治疗前后的关节疼痛值与开口度,观察药物不良反应。结果 肿痛安与布洛芬口服后,关节疼痛程度均明显缓解,开口度增大,两种药物疗效之间差异无统计学意义。布洛芬引起的药物不良反应多于肿痛安,且两者之间差异有统计学意义。结论 肿痛安治疗癌症放射治疗后颞下颌关节疼痛疗效确切,相对于非甾体类消炎药,肿痛安的不良反应较少,安全系数高,可作为非甾体类消炎药不耐受患者的替代药物。

关键词: 肿痛安, 放射治疗, 颞下颌关节疼痛

Abstract:

Objective This study aims to evaluate the effect of Zhongtongan in the treatment of temporomandibular joint(TMJ) pain after radiotherapy. Methods Patients diagnosed with TMJ pain after radiotherapy were selected. The test groups are treated with Zhongtongan, whereas the control groups were separately treated with ibuprofen and vitamin E. Visual analog scale values of pain and range of motion were observedalong with adverse drug reactions. Results Zhongtongan or ibuprofen alleviated the degree of TMJ pain and improved the range of motion. No significant difference was found between the effects of the two drugs. The adverse drug reactions of ibuprofen were more serious than those of Zhongtongan. A significant difference was found between the two drugs in terms of adverse drug reaction. Conclusion The effect of Zhongtongan in the treatment of TMJ pain was confirmed. Compared with non-steroidal anti-inflammatory drugs, Zhongtongan was found to be safer and has lessadverse drug reactions than ibuprofen. Furthermore, Zhongtongan can be used as an alternative medicine for patients intolerant to non-steroidal anti-inflammatory drugs.

Key words: Zhongtongan, radiotherapy, temporomandibular joint pain

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[2] 吕丹妮,李容林,杨光伟,李春阳. 放射治疗和化学治疗诱发性口腔黏膜炎的防治[J]. 国际口腔医学杂志, 2015, 42(2): 177-180.
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