Int J Stomatol

Inter J Stomatol ›› 2012, Vol. 39 ›› Issue (1): 86-88.doi: 10.3969/j.issn.1673-5749.2012.01.024

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Advances in the research of extracellular signal-regulated kinase 1/2 signaling pathway on promoting the expression of core binding factor α1 by mechanical strain

Wu Yuqiong, Jiang Lingyong, Fang Bing.   

  1. Center of Craniofacial Orthodontic, Dept. of Oral and Maxillofacial Surgery, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China; Oral Bioengineering and Regenerative Medicine Laboratory, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Received:2011-07-05 Revised:2011-10-25 Online:2012-01-01 Published:2012-01-01

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Abstract:

Core binding factor α1（Cbfα1） is a key gene in bone formation, which determines the mesenchymal stem cells differentiating to osteoblast. It’s available to control the differentiation of the bone cells, and maintain the normal skeletal development by adjusting the Cbfα1 expression. Mechanical strain promotes the expression of Cbfα1 by activating several signaling pathway, then adjusts skeletal development and formation, of which extracellular signal-regulated kinase1/2（ERK1/2） signaling pathway is a key one.

Key words: mechanical strain； core binding factor &alpha, 1； extracellular signal-regulated kinase 1/2； mesenchymal stem cell


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